Evidence map›Paper›PMID 34469137›Full record

ArticleJournal of medicinal chemistry2021

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent

Paolo Di Fruscia, Anna Carbone, Giovanni Bottegoni, Francesco Berti, Francesca Giacomina, Stefano Ponzano, Chiara Pagliuca, Annalisa Fiasella, Daniela Pizzirani, Jose Antonio Ortega and 14 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. SuFExableThe Journal of organic chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Paolo Di FrusciaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.ORCID 0000-0002-2914-0651
Anna CarboneD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Giovanni BottegoniComputational and Chemical Biology, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.ORCID 0000-0003-1251-583X
Francesco BertiD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Francesca GiacominaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Stefano PonzanoD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Chiara PagliucaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Annalisa FiasellaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Daniela PizziraniD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Jose Antonio OrtegaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Andrea NuzziD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Glauco TarozzoD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Luisa MengattoD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Roberta GiampàD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Ilaria PennaD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Debora RussoD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Elisa RomeoD3-Validation, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Maria SummaAnalytical Chemistry and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Rosalia BertorelliAnalytical Chemistry and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Andrea ArmirottiAnalytical Chemistry and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.ORCID 0000-0002-3766-8755
Sine Mandrup BertozziAnalytical Chemistry and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Angelo ReggianiD3-Validation, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Tiziano BandieraD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.
Fabio BertozziD3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163Genova, Italy.ORCID 0000-0001-7434-3688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of intracellular

Indexed as

AmidohydrolasesAnimalsAnti-Inflammatory AgentsEnzyme InhibitorsHumansMaleMiceMice, Inbred C57BLMicrosomes, LiverMolecular Docking SimulationMolecular StructureProtein BindingPyrazolesRatsRats, Sprague-DawleyStructure-Activity RelationshipAmidohydrolasesAnti-Inflammatory AgentsEnzyme InhibitorsNAAA protein, humanN-acylethanolamine-hydrolyzing acid amidase, ratPyrazolesTropanes

Identifiers

PMID34469137
PMCPMC8474119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.