ReviewPediatric nephrology (Berlin, Germany)2022
Differential diagnosis between syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome in children over 1 year: proposal for a simple algorithm.
Review in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Assessing the Role of Delta Copeptin in the Evaluation of SIAD and CSW.Indian journal of pediatrics · 2026Article
- Sodium and Water Homeostasis in Children: Pathogenesis, Diagnosis, and Treatment.Journal of clinical medicine · 2026Review
- The risk of sodium overcorrections in severe hyponatremia and the utility of desmopressin: a large retrospective study.Clinical kidney journal · 2025Article
- Case Report: Presumed cerebral salt wasting syndrome in a 10-week-old German Shorthaired Pointer.Frontiers in veterinary science · 2025Article
- A Boy with Reset Osmostat Who Developed Chronic Hyponatremia due to Hypothalamic Injury Caused By a Giant Arachnoid CystJournal of clinical research in pediatric endocrinology · 2024Article
- Chronic hyponatremia in a 19-month-old child with gross developmental delay: Answers.Pediatric nephrology (Berlin, Germany) · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Hyponatremia, especially if acute and severe, can be a life-threatening condition. Several conditions can trigger hyponatremia. In this review, we will discuss two conditions that can determine euvolemic hyponatremia: the cerebral/renal salt wasting (CRSW) syndrome and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), including the two subtypes: reset osmostat (RO) and nephrogenic syndrome of inappropriate antidiuresis (NSIAD) and their differential diagnoses. Despite the passage of over 70 years since its first description, to date, the true etiopathogenesis of CRSW syndrome, a rare cause of hypovolemic/euvolemic hyponatremia, is almost unknown. SIADH, including RO and NSIAD, is sometimes difficult to differentiate from CRSW syndrome; in its differential diagnosis, the clinical approach based on the evaluation of the extracellular volume (ECV) was proven insufficient. We therefore suggest a simple diagnostic algorithm based on the assessment of the degree of hyponatremia, urinary osmolality, and the assessment of the fraction of urate excretion (FEUa) in conditions of hyponatremia and after serum sodium correction, to be applied in children over 1 year of life.
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