Evidence map›Paper›PMID 34468814›Full record

Trial reportArchives of toxicology2021

Inhalation of hydrogenated vegetable oil combustion exhaust and genotoxicity responses in humans.

Rebecca Harnung Scholten, Yona J Essig, Martin Roursgaard, Annie Jensen, Annette M Krais, Louise Gren, Katrin Dierschke, Anders Gudmundsson, Aneta Wierzbicka, Peter Møller

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Rebecca Harnung ScholtenDepartment of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen K, Denmark.
Yona J EssigDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Martin RoursgaardDepartment of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen K, Denmark.
Annie JensenDepartment of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen K, Denmark.
Annette M KraisDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Louise GrenErgonomics and Aerosol Technology, Department of Design Sciences, Lund University, Box 118, 22100, Lund, Sweden.
Katrin DierschkeDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Anders GudmundssonErgonomics and Aerosol Technology, Department of Design Sciences, Lund University, Box 118, 22100, Lund, Sweden.
Aneta WierzbickaErgonomics and Aerosol Technology, Department of Design Sciences, Lund University, Box 118, 22100, Lund, Sweden.
Peter MøllerDepartment of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen K, Denmark. pemo@sund.ku.dk.ORCID 0000-0002-2021-1249
Lund University · SEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofuels from vegetable oils or animal fats are considered to be more sustainable than petroleum-derived diesel fuel. In this study, we have assessed the effect of hydrogenated vegetable oil (HVO) exhaust on levels of DNA damage in peripheral blood mononuclear cells (PBMCs) as primary outcome, and oxidative stress and inflammation as mediators of genotoxicity. In a randomized cross-over study, healthy humans were exposed to filtered air, inorganic salt particles, exhausts from combustion of HVO in engines with aftertreatment [i.e. emission with nitrogen oxides and low amounts of particulate matter less than 2.5 µm (approximately 1 µg/m

Indexed as

AdultAntioxidantsBiofuelsCross-Over StudiesDNA DamageDNA RepairFemaleHumansInhalation ExposureLeukocytes, MononuclearMaleMiddle AgedNitrogen OxidesOxidative StressParticulate MatterPlant OilsAntioxidantsBiofuelsNitrogen OxidesParticulate MatterPlant OilsVehicle EmissionsAerosolBiofuelControlled human exposureDNA damageGenotoxicityInflammationOxidative stress

Identifiers

PMID34468814
OpenAlexW3197482246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.