ReviewApplied microbiology and biotechnology2021
Production of bioactive plant secondary metabolites through in vitro technologies-status and outlook.
Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed.
- An aromatic substrate prenyltransferase involved in the chemical diversification of flavonoids in Glycyrrhiza glabra.Planta · 2026Article
- Marigold suspension cell culture as production system for recombinant DsRed and brazzein.Plant cell reports · 2026Article
- Morphological Traits, Accumulation and Compartmentalization of Phenolic Compounds and Cadmium (CDMolecules (Basel, Switzerland) · 2026Article
- The Convergence of Biotechnological Strategies in Medicinal Plants: From Individual Approaches Toward an Integrated Systems Framework.International journal of molecular sciences · 2026Review
- PlantInternational journal of molecular sciences · 2026Review
- The Genetic Transformation Mechanism and Application of Plant Hairy Roots.Plants (Basel, Switzerland) · 2026Review
- Application of Nanoparticles in Plant In Vitro Culture for Micropropagation and Secondary Metabolite Production: A Review.Plants (Basel, Switzerland) · 2026Review
- In Vitro Regeneration ofAntioxidants (Basel, Switzerland) · 2026Article
- Effect of Methyl Jasmonate on the Growth, Antioxidant Potential, and Phenolic Compound Synthesis ofBiology · 2026Article
- Dataset on the differential metabolite composition of ripe and green fruit coats ofData in brief · 2026Article
- Immersion Frequency Optimisation and Species-Specific Metabolic Profiles of Colchicum autumnale and Colchicum bivonae in Temporary Immersion Systems.Plants (Basel, Switzerland) · 2026Article
- Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole-Cell Factory Saccharomyces Cerevisae.Chembiochem : a European journal of chemical biology · 2026Review
- Alkaloids from In Vitro CulturedPlants (Basel, Switzerland) · 2026Article
- Selenium nanoparticles: Eco-friendly synthesis, biological activities and biomedical applications - A comprehensive review.Materials today. Bio · 2026Review
- Seizing the key nodes in glabridin biosynthesis network: identification of enzymes for producing licorice hairy roots with high levels of glabridin.Molecular horticulture · 2026Article
- Review
- Bioactive Components ofAntioxidants (Basel, Switzerland) · 2026Review
- Anticancer potential ofFrontiers in pharmacology · 2026Article
- Enhancing the pectolinarigenin production inFrontiers in plant science · 2026Article
- Nano-Elicitation Approaches for Boosting Secondary Metabolites in Medicinal Plant Cell Cultures.Plants (Basel, Switzerland) · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medicinal plants have been used by mankind since ancient times, and many bioactive plant secondary metabolites are applied nowadays both directly as drugs, and as raw materials for semi-synthetic modifications. However, the structural complexity often thwarts cost-efficient chemical synthesis, and the usually low content in the native plant necessitates the processing of large amounts of field-cultivated raw material. The biotechnological manufacturing of such compounds offers a number of advantages like predictable, stable, and year-round sustainable production, scalability, and easier extraction and purification. Plant cell and tissue culture represents one possible alternative to the extraction of phytochemicals from plant material. Although a broad commercialization of such processes has not yet occurred, ongoing research indicates that plant in vitro systems such as cell suspension cultures, organ cultures, and transgenic hairy roots hold a promising potential as sources for bioactive compounds. Progress in the areas of biosynthetic pathway elucidation and genetic manipulation has expanded the possibilities to utilize plant metabolic engineering and heterologous production in microorganisms. This review aims to summarize recent advances in the in vitro production of high-value plant secondary metabolites of medicinal importance.Key points• Bioactive plant secondary metabolites are important for current and future use in medicine• In vitro production is a sustainable alternative to extraction from plants or costly chemical synthesis• Current research addresses plant cell and tissue culture, metabolic engineering, and heterologous production.
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