Evidence map›Paper›PMID 34468781›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Eribulin improves tumor oxygenation demonstrated by

Tomoki Bo, Hironobu Yasui, Tohru Shiga, Yuki Shibata, Masaki Fujimoto, Motofumi Suzuki, Kei Higashikawa, Naoki Miyamoto, Osamu Inanami, Yuji Kuge

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tomoki BoLaboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.
Hironobu YasuiLaboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan. yassan@vetmed.hokudai.ac.jp.ORCID http://orcid.org/0000-0002-6757-1110
Tohru ShigaAdvanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Yuki ShibataCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.ORCID http://orcid.org/0000-0002-2532-9916
Masaki FujimotoLaboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.
Motofumi SuzukiLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.ORCID http://orcid.org/0000-0003-0348-9422
Kei HigashikawaCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Naoki MiyamotoDivision of Quantum Science and Engineering, Faculty of Engineering, Hokkaido University, Sapporo, Japan.
Osamu InanamiLaboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.ORCID http://orcid.org/0000-0001-7895-3918
Yuji KugeCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.ORCID http://orcid.org/0000-0002-0483-9706
Hokkaido University · JPHokkaido University of Science · JPFukushima Medical University · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEribulin, an inhibitor of microtubule dynamics, is known to show antitumor effects through its remodeling activity in the tumor vasculature. However, the extent to which the improvement of tumor hypoxia by eribulin affects radio-sensitivity remains unclear. We utilized 1-(2,2-dihydroxymethyl-3-

methodsMice bearing human breast cancer MDA-MB-231 cells or human lung cancer NCI-H1975 cells were administered a single dose of eribulin. After administration, mice were injected with

resultsEribulin significantly reduced

conclusionThese results demonstrated that

Indexed as

FuransKetonesLung NeoplasmsPositron Emission Tomography Computed TomographyTumor HypoxiaAnimalsCell Line, TumorHeterograftsHumansMicePolyether PolyketideseribulinFuransKetonesPolyether Polyketides18F-DiFAEribulinHypoxiaPET/CT imagingRadiation

Identifiers

PMID34468781
OpenAlexW3196372603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.