Evidence map›Paper›PMID 34468586›Full record

ArticleRevista peruana de medicina experimental y salud publica

Procedure for infusion of autologous mitochondria through the carotid artery in porcine brain.

Miguel A Orrego, Samuel Levy, Cory Kelly, Gianfranco Arroyo, Luz Toribio, Hector H García, Melanie Walker

Open access · diamondAbstract read
In one paragraph

Article in Revista peruana de medicina experimental y salud publica. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Miguel A OrregoLaboratorio de Inmunopatología en Neurocisticercosis, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID http://orcid.org/0000-0003-0036-427X
Samuel LevyUniversidad de Washington, Escuela de Medicina, Departamento de Cirugía Neurológica y Centro de Neurociencia Aplicada, Seattle, Washington, Estados Unidos.ORCID http://orcid.org/0000-0001-8175-4717
Cory KellyUniversidad de Washington, Escuela de Medicina, Departamento de Cirugía Neurológica y Centro de Neurociencia Aplicada, Seattle, Washington, Estados Unidos.ORCID http://orcid.org/0000-0002-0010-5633
Gianfranco ArroyoLaboratorio de Inmunopatología en Neurocisticercosis, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID http://orcid.org/0000-0001-8743-5012
Luz ToribioLaboratorio de Inmunopatología en Neurocisticercosis, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID http://orcid.org/0000-0002-2818-4521
Hector H GarcíaLaboratorio de Inmunopatología en Neurocisticercosis, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID http://orcid.org/0000-0002-4633-6269
Melanie WalkerUniversidad de Washington, Escuela de Medicina, Departamento de Cirugía Neurológica y Centro de Neurociencia Aplicada, Seattle, Washington, Estados Unidos.ORCID http://orcid.org/0000-0002-8995-4657
Universidad Peruana Cayetano Heredia · PEUniversity of Washington · US

Funding

Training in Parasitic Diseases and Central Nervous System Infections in Peru.D43TW001140 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GARCIA, HECTOR HUGO, GILMAN, ROBERT H · 1999 to 2025
$5.7M
FIC NIH HHS D43 TW001140
6 · The paper itself

Abstract

Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.

Indexed as

Central Nervous System DiseasesMitochondriaAnimalsBrainCarotid ArteriesSwine

Identifiers

PMID34468586
PMCPMC8800344
OpenAlexW3185064459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.