Evidence map›Paper›PMID 34468209›Full record

ArticleBiopreservation and biobanking2021

Microsatellite Markers in Biobanking: A New Multiplexed Assay.

Gretchen Smith, Debra Mathews, Samuel Sander-Effron, Deborah Requesens, Nahid Turan, Laura Scheinfeldt

Abstract read
In one paragraph

Article in Biopreservation and biobanking, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gretchen SmithCoriell Institute for Medical Research, Camden, New Jersey, USA.
Debra MathewsBerman Institute of Bioethics, Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Samuel Sander-EffronCoriell Institute for Medical Research, Camden, New Jersey, USA.
Deborah RequesensCoriell Institute for Medical Research, Camden, New Jersey, USA.
Nahid TuranCoriell Institute for Medical Research, Camden, New Jersey, USA.
Laura ScheinfeldtCoriell Institute for Medical Research, Camden, New Jersey, USA.ORCID 0000-0001-6529-6701

Funding

The NIGMS Human Genetic Cell Repository Cooperative Agreement (U42) ApplicationU42GM115336 · NIGMS · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI Nahid Turan · 2015 to 2026
$28.5M
Sample Repository for Human Genetic ResearchU41HG008736 · NHGRI · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI RESCH, ALISSA MARIE · 2016 to 2020
$4.3M
NHGRI NIH HHS U41 HG008736NIGMS NIH HHS U42 GM115336
6 · The paper itself

Abstract

Microsatellites, or MSATs, offer a fast and cost-effective way for biobanks to establish a biospecimen genetic profile. Importantly, this genetic profile can be used to authenticate multiple submissions derived from the same individual as well as biospecimens derived from the same original sample submission over time. While the Certificate of Confidentiality provided by the National Institutes of Health offers some meaningful protection to prevent the disclosure of potentially identifiable information to entities within the United States, we consider, in this study, the potential to offer additional protection to participants who choose to donate to biobanks by minimizing the use of forensic Combined DNA Index System (CODIS) MSAT markers in biobanking. To this end, we report the design and validation of a new multiplexed MSAT assay that does not include CODIS markers for use in biobanking operations and quality control management.

Indexed as

Biological Specimen BanksConfidentialityDisclosureHumansMicrosatellite RepeatsNational Institutes of Health (U.S.)United Statesbiobankingbiospecimen authenticationmicrosatellite

Identifiers

PMID34468209
PMCPMC8665806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.