Evidence map›Paper›PMID 34468176›Full record

ArticleJournal of virology2021

Repair of APOBEC3G-Mutated Retroviral DNA

Karen Salas-Briceno, Susan R Ross

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Journal of virology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Karen Salas-BricenoDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-2166-0035
Susan R RossDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3094-3769
University of Illinois Chicago · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Role of APOBEC3 in in vivo Restriction of Retrovirus InfectionR01AI085015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 2010 to 2019
$3.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI 085015NCATS NIH HHS UL1 TR002003NIAID NIH HHS R01 AI085015
6 · The paper itself

Abstract

Apolipoprotein B mRNA editing enzyme catalytic subunit 3 (APOBEC3) proteins are critical for the control of infection by retroviruses. These proteins deaminate cytidines in negative-strand DNA during reverse transcription, leading to G-to-A changes in coding strands. Uracil DNA glycosylase (UNG) is a host enzyme that excises uracils in genomic DNA, which the base excision repair machinery then repairs. Whether UNG removes uracils found in retroviral DNA after APOBEC3-mediated mutation is not clear, and whether this occurs

Indexed as

RetroviridaeRetroviridae InfectionsAnimalsAPOBEC-3G DeaminaseDNA RepairDNA, ViralHEK293 CellsHumansMiceMice, KnockoutNIH 3T3 CellsUracil-DNA GlycosidaseAPOBEC-3G DeaminaseAPOBEC3G protein, mouseDNA, ViralUracil-DNA GlycosidaseAPOBEC3base-excision repairmurine retrovirusuracil DNA glycosylase

Identifiers

PMID34468176
PMCPMC8549519
OpenAlexW3198103162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.