Evidence map›Paper›PMID 34468164›Full record

ArticlemSphere2021

Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-Omics.

Santiago Chávez, Michael D Urbaniak, Corinna Benz, Pablo Smircich, Beatriz Garat, José R Sotelo-Silveira, María Ana Duhagon

Abstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Pathogens (Basel, Switzerland) · 2025
    Review
  4. Stage-specific MCM protein expression inFrontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Translational control byRNA (New York, N.Y.) · 2023
    Article
  7. Article
  8. The ElusivePathogens (Basel, Switzerland) · 2023
    Review
  9. Modulation of Virulence Factors duringPathogens (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Santiago ChávezLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.ORCID 0000-0002-6312-7063
Michael D UrbaniakBiomedical and Life Sciences, Faculty of Health and Medicine, Lancaster Universitygrid.9835.7, Lancaster, United Kingdom.
Corinna BenzBiomedical and Life Sciences, Faculty of Health and Medicine, Lancaster Universitygrid.9835.7, Lancaster, United Kingdom.
Pablo SmircichLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Beatriz GaratLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
José R Sotelo-SilveiraDepartamento de Genómica, Instituto de Investigaciones Biológicas Clemente Estable, Ministerio de Educación y Cultura, Montevideo, Uruguay.
María Ana DuhagonLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.ORCID 0000-0001-6468-1704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trypanosoma cruzi is the etiological agent for Chagas disease, a neglected parasitic disease in Latin America. Gene transcription control governs the eukaryotic cell replication but is absent in trypanosomatids; thus, it must be replaced by posttranscriptional regulatory events. We investigated the entrance into the T. cruzi replicative cycle using ribosome profiling and proteomics on G

Indexed as

Gene Expression ProfilingGene Expression Regulation, DevelopmentalLife Cycle StagesProtein Processing, Post-TranslationalProteomeProteomicsProtozoan ProteinsRibosomesRNA, ProtozoanTranscriptomeTrypanosoma cruziProteomeProtozoan ProteinsRNA, Protozoancell cyclecell proliferationChagas’ diseasegenomicsmass spectrometryposttranscriptionproteomicsregulonribosome profilingtranslational controlTrypanosomaTrypanosoma cruzi

Identifiers

PMID34468164
PMCPMC8550152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.