ArticleJournal of child psychology and psychiatry, and allied disciplines2022
The relationship between brain structure and general psychopathology in preadolescents.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-19 pandemic.BMC public health · 2025Trial
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- GenX exposure induces neurodevelopmental impairment and synaptic toxicity in hESC-derived cerebral organoids.Materials today. Bio · 2026Article
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Changes in white matter volume and cortical thickness predict internalizing symptoms during early adolescence.Journal of psychopathology and clinical science · 2026Article
- Article
- Structural Brain Correlates of Multidomain Resilience Among Youth Exposed to Neighborhood Disadvantage.Biological psychiatry global open science · 2025Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence.Molecular psychiatry · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.Psychological medicine · 2025Article
- Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems.NeuroImage. Clinical · 2025Article
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions.Human brain mapping · 2024Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions.Developmental cognitive neuroscience · 2024Article
- Article
- Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Loss of control eating in children is associated with altered cortical and subcortical brain structure.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundAn emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging.
methodsThis study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study
resultsHigher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents.
conclusionsThe current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.