Evidence map›Paper›PMID 34467856›Full record

ArticleMedical hypotheses2021

Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19.

Boxuan Yu, Ligen Yu, Daniel J Klionsky

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypotheses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Boxuan YuHwa Chong Institution, 661 Bukit Timah Road, Singapore 269734, Singapore. Electronic address: boxuanyu2003@gmail.com.
Ligen YuTalent Recruitment and Career Support (TRACS) Office and Bibliometrics Analysis, Nanyang Technological University, Singapore.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States.
Hwa Chong Institution · SGNanyang Technological University · SGUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.

Indexed as

COVID-19OvernutritionCytokine Release SyndromeCytokinesHumansNutritional StatusSARS-CoV-2CytokinesCOVID-19Cytokine stormHyperinflammationImmune systemNutrition acquisitionOvernutrition

Identifiers

PMID34467856
PMCPMC8379086
OpenAlexW3195547448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.