ArticleeLife2021
Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Remaking an exit: dynamic regulation of ER exit sites by post-translational modifications.Trends in cell biology · 2026Review
- Coupling of cargo to the autophagy receptor is a critical step in ER-phagy.Science advances · 2026Article
- Biomolecular Condensates in and Around the ER-Golgi Interface.Sub-cellular biochemistry · 2026Review
- A multichaperone condensate enhances protein folding in the endoplasmic reticulum.Nature cell biology · 2025Article
- Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.Trends in cell biology · 2025Review
- Article
- Protein aggregates and biomolecular condensates: implications for human health and disease.Frontiers in molecular biosciences · 2025Review
- PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions.The Journal of cell biology · 2024Article
- RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum.Autophagy · 2024Article
- Sestrin2 drives ER-phagy in response to protein misfolding.Developmental cell · 2024Article
- Membrane nanotubes transform into double-membrane sheets at condensate droplets.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Protein condensates in the the secretory pathway: Unraveling biophysical interactions and function.Biophysical journal · 2024Review
- Different ER-plasma membrane tethers play opposing roles in autophagy of the cortical ER.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Role of β-cell autophagy in β-cell physiology and the development of diabetes.Journal of diabetes investigation · 2024Review
- COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation.Scientific reports · 2024Article
- The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes.Molecular biology of the cell · 2024Article
- UVRAG cooperates with cargo receptors to assemble the ER-phagy site.The EMBO journal · 2023Article
- Autophagy of the ER: the secretome finds the lysosome.The FEBS journal · 2023Review
- Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.Redox biology · 2023Article
- Hypothermia increases cold-inducible protein expression and improves cerebellar-dependent learning after hypoxia ischemia in the neonatal rat.Pediatric research · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Smriti ParasharDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, United States.
Ravi ChidambaramDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, United States.
Shuliang ChenDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, United States.
Christina R LiemDivision of Biological Sciences, University of California at San Diego, La Jolla, California, United States.
Eric GriffisNikon Imaging Center, University of California at San Diego, La Jolla, California, United States.
Gerard G LambertDepartment of Neurosciences, University of California at San Diego, La Jolla, California, United States.
Nathan C ShanerDepartment of Neurosciences, University of California at San Diego, La Jolla, California, United States.
Matthew WorthamDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California at San Diego, La Jolla, California, United States.
Jesse C HayDivision of Biological Sciences and Center for Structural & Functional Neuroscience, University of Montana, Missoula, United States.
Susan Ferro-NovickDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, United States.ORCID 0000-0001-8714-7352
University of California San Diego · USNikon (United States) · USUniversity of Montana · US
Funding
Nkx6 gene function in pancreas developmentR01DK068471 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WORTHAM, MATTHEW · 2004 to 2024
$6.6MThe diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality controlR35GM131681 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Susan FERRO-NOVICK · 2019 to 2026
$5.5MDesigning and deploying an expanded color palette of voltage indicators engineered for multiphoton microscopyU01NS113294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ST-PIERRE, FRANCOIS, TOLIAS, ANDREAS · 2019 to 2021
$3.7MThe connection between ER-phagy, ER structure and hereditary spastic paraplegiasR01NS117440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FERRO-NOVICK, SUSAN · 2020 to 2024
$2.4MBioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for NeuromodulationU01NS099709 · NINDS · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, MOORE, CHRISTOPHER I · 2016 to 2018
$2.4MFluorescent proteins for superresolution imagingR01GM109984 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHANER, NATHAN CHRISTOPHER · 2014 to 2018
$1.8MProbes for Luminescence-based Superresolution MicroscopyR01GM121944 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHANER, NATHAN CHRISTOPHER · 2017 to 2020
$1.3MRegulation of ER to Golgi Transport byLuminal CalciumR15GM106323 · NIGMS · UNIVERSITY OF MONTANA · PI HAY, JESSE C · 2013 to 2022
$1.3MHighly specific control of neurons with photoswitchable bioluminescent optogenetics.R21EY030716 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHANER, NATHAN CHRISTOPHER · 2019 to 2019
$486kNEI NIH HHS R21 EY030716NIDDK NIH HHS R01 DK068471NIGMS NIH HHS R01 GM109984NIGMS NIH HHS R01 GM121944NIGMS NIH HHS R15 GM106323NIGMS NIH HHS R35 GM131681NINDS NIH HHS R01 NS117440NINDS NIH HHS U01 NS099709NINDS NIH HHS U01 NS113294
Abstract
The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin
Indexed as
AnimalsAutophagyCarrier ProteinsCell Line, TumorEndoplasmic ReticulumHEK293 CellsHumansLysosomesMembrane ProteinsMiceMice, KnockoutProinsulinProtein AggregatesProtein FoldingCarrier ProteinsMembrane ProteinsProinsulinProtein Aggregatescell biologyER-phagyER structureLunaparkmisfolded neuropeptidesmisfolded prohormonesprotein quality controlSEC24C
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.