Evidence map›Paper›PMID 34467654›Full record

ArticleCytoskeleton (Hoboken, N.J.)2021

Variable fluid flow regimes alter human brain microvascular endothelial cell-cell junctions and cytoskeletal structure.

Dilshan Ranadewa, Jingwen Wu, Vignesh A Subramanianbalachandar, Robert L Steward

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytoskeleton (Hoboken, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Vascularizing the brainiScience · 2022
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dilshan RanadewaDepartment of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA.
Jingwen WuDepartment of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA.
Vignesh A SubramanianbalachandarDepartment of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA.
Robert L StewardDepartment of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA.
University of Central Florida · US

Funding

Endothelial Cell Mechanical Dysfunction in Early Stage AtherosclerosisK25HL132098 · NHLBI · UNIVERSITY OF CENTRAL FLORIDA · PI STEWARD, ROBERT · 2016 to 2020
$737k
Division of Civil, Mechanical and Manufacturing Innovation 2045750NHLBI NIH HHS K25 HL132098
6 · The paper itself

Abstract

The human brain microvasculature is constantly exposed to variable fluid flow regimes and their influence on the endothelium depends in part on the synchronous cooperative behavior between cell-cell junctions and the cytoskeleton. In this study, we exposed human cerebral microvascular endothelial cells to a low laminar flow (1 dyne⋅cm

Indexed as

Endothelial CellsIntercellular JunctionsBrainCadherinsCytoskeletonEndotheliumHumansCadherinscell areacell-cell junctionsendothelial cellsF-actinfluid flow

Identifiers

PMID34467654
PMCPMC8500649
OpenAlexW3198656970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.