Evidence map›Paper›PMID 34467645›Full record

ReviewMaternal & child nutrition2022

Animal source foods, rich in essential amino acids, are important for linear growth and development of young children in low- and middle-income countries.

Panam Parikh, Richard Semba, Mark Manary, Sumathi Swaminathan, Emorn Udomkesmalee, Rolf Bos, Bee Koon Poh, Nipa Rojroongwasinkul, Jan Geurts, Rini Sekartini and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Maternal & child nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 7 countries.

Panam ParikhFrieslandCampina, Amersfoort, The Netherlands.
Richard SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mark ManaryDepartment of Paediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Sumathi SwaminathanSt John's Research Institute, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.
Emorn UdomkesmaleeInstitute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
Rolf BosFrieslandCampina, Amersfoort, The Netherlands.
Bee Koon PohNutritional Sciences Programme & Centre for Community Health, Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Nipa RojroongwasinkulInstitute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
Jan GeurtsFrieslandCampina, Amersfoort, The Netherlands.ORCID 0000-0002-8604-341X
Rini SekartiniFaculty of Medicine, Department of Pediatrics, University of Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Tran Thuy NgaDepartment of Occupational and School Nutrition, National Institute of Nutrition (NIN), Hanoi, Vietnam.
FrieslandCampina (Netherlands) · NLMahidol University · THJohns Hopkins University · USNational Institute of Nutrition · VNSt. John's National Academy of Health Sciences · INUniversity Kebangsaan Malaysia Medical Centre · MYUniversity of Indonesia · IDWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth faltering under 5 years of age is unacceptably high worldwide, and even more children, while not stunted, fail to reach their growth potential. The time between conception and 2 years of age is critical for development. The period from 6 to 23 months, when complementary foods are introduced, coincides with a time when growth faltering and delayed neurocognitive developments are most common. Fortunately, this is also the period when diet exercises its greatest influence. Growing up in an adverse environment, with a deficient diet, as typically seen in low- and middle-income countries (LMICs), hampers growth and development of children and prevents them from realising their full developmental and economic future potential. Sufficient nutrient availability and utilisation are paramount to a child's growth and development trajectory, especially in the period after breastfeeding. This review highlights the importance of essential amino acids (EAAs) in early life for linear growth and, likely, neurocognitive development. The paper further discusses signalling through mammalian target of rapamycin complex 1 (mTORC1) as one of the main amino acid (AA)-sensing hubs and the master regulator of both growth and neurocognitive development. Children in LMICs, despite consuming sufficient total protein, do not meet their EAA requirements due to poor diet diversity and low-quality dietary protein. AA deficiencies in early life can cause reductions in linear growth and cognition. Ensuring AA adequacy in diets, particularly through inclusion of nutrient-dense animal source foods from 6 to 23 months, is strongly encouraged in LMICs in order to compensate for less than optimal growth during complementary feeding.

Indexed as

Amino Acids, EssentialDeveloping CountriesAnimalsChild, PreschoolDietGrowth and DevelopmentHumansInfantInfant Nutritional Physiological PhenomenaMammalsAmino Acids, Essentialanimal source proteinargininecognitiongrowth falteringleucinemTORC1tryptophan

Identifiers

PMID34467645
PMCPMC8710096
OpenAlexW3197572917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.