ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021
Liver transplantation from active COVID-19 donors: A lifesaving opportunity worth grasping?
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of recent COVID-19 infection on liver and kidney transplantation - a worldwide meta-analysis and systematic review.Frontiers in immunology · 2025Pooled it
- Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: A systematic review.Anaesthesia, critical care & pain medicine · 2022Pooled it
- Article
- The Impact and Evolution of COVID-19 on Liver Transplant Recipients Throughout the Pandemic "Waves" in a Single Center.Viruses · 2025Observational
- Updates on Donor-Derived Infection in Solid Organ Transplantation, Report from the 2024 GTI (Infection and Transplantation Group) Annual Meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Perspective on donor-derived infections in Italy.Transplant infectious disease : an official journal of the Transplantation Society · 2024Review
- The learning curve of COVID-19 and organ donation: Potential missed opportunities in the COVID era.Heliyon · 2024Article
- COVID-19 in organ donors: An organ procurement organization perspective.Transplant infectious disease : an official journal of the Transplantation Society · 2024Article
- Acceptance of Organs from Deceased Donors With Resolved or Active SARS-CoV-2 Infection: A Survey From the Council of Europe.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Recommendations for SARS-CoV-2 testing and organ procurement from deceased donors in the Republic of Korea.Korean journal of transplantation · 2023Review
- Outcomes of COVID-19-Positive Donor Heart Transplantation in the United States.Journal of the American Heart Association · 2023Article
- Review
- Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not.Journal of liver transplantation · 2023Article
- COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells.World journal of gastroenterology · 2023Review
- COVID-19 in liver transplant patients: Impact and considerations.World journal of transplantation · 2023Review
- Successful lung transplantation using an allograft from a COVID-19-recovered donor: a potential role for subgenomic RNA to guide organ utilization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- How to Structure a Successful Organ Donation and Transplantation System in Eight (Not So Easy) Steps: An Italian Case Study.Transplant international : official journal of the European Society for Organ Transplantation · 2023Review
- COVID-19 in patients with liver disease and liver transplant: clinical implications, prevention, and management.Therapeutic advances in gastroenterology · 2023Review
- Comparative outcomes for over 100 deceased donor kidney transplants from SARS-CoV-2 positive donors: A single-center experience.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- A new chapter in an evolving pandemic: Successful pediatric liver transplantation with SARS-CoV-2+ donors.Pediatric transplantation · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 pandemic dramatically impacted transplantation landscape. Scientific societies recommend against the use of donors with active SARS-CoV-2 infection. Italian Transplant Authority recommended to test recipients/donors for SARS-CoV-2-RNA immediately before liver transplant (LT) and, starting from November 2020, grafts from deceased donors with active SARS-CoV-2 infection were allowed to be considered for urgent-need transplant candidates with active/resolved COVID-19. We present the results of the first 10 LTs with active COVID-19 donors within an Italian multicenter series. Only two recipients had a positive molecular test at LT and one of them remained positive up to 21 days post-LT. None of the other eight recipients was found to be SARS-CoV-2 positive during follow-up. IgG against SARS-CoV-2 at LT were positive in 80% (8/10) of recipients, and 71% (5/7) showed neutralizing antibodies, expression of protective immunity related to recent COVID-19. In addition, testing for SARS-CoV-2 RNA on donors' liver biopsy at transplantation was negative in 100% (9/9), suggesting a very low risk of transmission with LT. Immunosuppression regimen remained unchanged, according to standard protocol. Despite the small number of cases, these data suggest that transplanting livers from donors with active COVID-19 in informed candidates with SARS-CoV-2 immunity, might contribute to safely increase the donor pool.
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