Evidence map›Paper›PMID 34467475›Full record

ArticleMycopathologia2021

The Change in the Neutrophil/Lymphocyte Ratio Predicts the Prognosis of Patients with Cryptococcal Meningitis.

Keming Zhang, Hang Li, Lei Zhang, Wanqing Liao, Liangqi Cai, Xinhua Li, Weihua Pan, Qilong Zhang

Abstract read
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In one paragraph

Article in Mycopathologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keming ZhangShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Hang LiShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Lei ZhangShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Wanqing LiaoShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Liangqi CaiDepartment of Dermatology, the First Affiliated Hospital of Xiamen University, Xiamen, 361000, People's Republic of China.
Xinhua LiTaiyuan Central Hospital, Taiyuan, 030009, Shanxi, People's Republic of China.
Weihua PanShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China. panweihua9@sina.com.
Qilong ZhangDepartment of Neurology, Jiangxi Chest Hospital, Nanchang, 330000, Jiangxi, People's Republic of China.

Funding

Chinese Academy of Engineering 2019-XY-33National Natural Science Foundation of China 31770161 and 82072257Shanghai Municipal Commission of Health and Family Planning 2017ZZ01024-001Shanghai Sailing Program 19YF1448000Shanghai Science and Technology Committee 17DZ2272900 and 14495800500the Major National R&D Projects of the National Health Department 2018ZX10101003
6 · The paper itself

Abstract

purposeThe neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied in many diseases. However, their roles in cryptococcal meningitis (CM) are unclear. The purpose of this article was to analyse the roles of the PLR and NLR in CM patients during treatment.

methods139 newly diagnosed CM patients were enrolled. We divided patients into two groups: the successful group (n = 121) and the failure group (n = 18) based on the prognosis of patients. Then, we analyzed changes in clinical data of two groups, which were measured at the time of admission, after 2 weeks and 4 weeks in the hospital. Then the patients were divided into HIV group (n = 26) and non-HIV group (n = 113) to determine whether HIV status had an impact on the prognosis and clinical data of patients.

resultsMost patients were male living in rural areas; headache was the most common symptom before admission. In the subgroup analysis based on HIV status, there were significantly fewer patients with HIV (26 individuals) than without HIV (113 individuals), and 40.7% non-HIV CM patients had no underlying diseases. There was no significant difference in prognosis (p = 0.746), lymphocytes (p = 0.109) or neutrophils (p = 0.269) between patients with and without HIV. A mixed-effect model indicated that there was no difference (p = 0.171) in PLR between successful group and failure group. However, the change of NLR was statistically significant (p = 0.004 < 0.05) between successful group and failure group.

conclusionAn increase in the NLR during treatment may be used as an indicator of treatment failure.

Indexed as

Meningitis, CryptococcalNeutrophilsHumansLymphocytesMalePlatelet CountPrognosisRetrospective StudiesCryptococcus neoformansMeningitisMixed-effect modelNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioPrognosis

Identifiers

PMID34467475

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