Evidence map›Paper›PMID 34467463›Full record

ReviewJournal of cardiovascular translational research2022

Potential of Phage Display Antibody Technology for Cardiovascular Disease Immunotherapy.

Soo Ghee Yeoh, Jia Siang Sum, Jing Yi Lai, W Y Haniff W Isa, Theam Soon Lim

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Soo Ghee YeohInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Jia Siang SumInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Jing Yi LaiInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, Penang, Malaysia.
W Y Haniff W IsaSchool of Medical Sciences, Department of Medicine, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia.
Theam Soon LimInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, Penang, Malaysia. theamsoon@usm.my.ORCID 0000-0002-0656-3045

Funding

Malaysian Ministry of Higher Education through the Fundamental Research Grant Scheme FRGS/1/2018/STG05/USM/02/2 - (203/CIPPM/6711658)
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD includes coronary artery diseases such as angina, myocardial infarction, and stroke. "Lipid hypothesis" which is also known as the cholesterol hypothesis proposes the linkage of plasma cholesterol level with the risk of developing CVD. Conventional management involves the use of statins to reduce the serum cholesterol levels as means for CVD prevention or treatment. The regulation of serum cholesterol levels can potentially be regulated with biological interventions like monoclonal antibodies. Phage display is a powerful tool for the development of therapeutic antibodies with successes over the recent decade. Although mainly for oncology, the application of monoclonal antibodies as immunotherapeutic agents could potentially be expanded to CVD. This review focuses on the concept of phage display for antibody development and discusses the potential target antigens that could potentially be beneficial for serum cholesterol management.

Indexed as

Anticholesteremic AgentsBacteriophagesCardiovascular DiseasesCholesterol, LDLHumansImmunotherapyProprotein Convertase 9TechnologyAnticholesteremic AgentsCholesterol, LDLProprotein Convertase 9Activin A receptor type II–like kinase 1Angiopoietin-like proteinsAntibody phage displayApolipoprotein C-IIICardiovascular diseaseImmunotherapyLipoprotein lipaseMonoclonal antibodiesPerilipinProprotein convertase subtilisin/kexin type 9

Identifiers

PMID34467463

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.