Evidence map›Paper›PMID 34467444›Full record

ArticleAAPS PharmSciTech2021

Non-intuitive Behavior of Polymer-Ciprofloxacin Nanoconjugate Suspensions: a Tool for Flexible Oral Drug Delivery.

Amos Abioye, Maitham Naqvi, Dillan Pattni, Aderonke Ayinke Adepoju-Bello

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Amos AbioyeLloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida, USA. amos_abioye@pba.edu.
Maitham NaqviLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Dillan PattniLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Aderonke Ayinke Adepoju-BelloDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.
De Montfort University · GBPalm Beach Atlantic University · USUniversity of Lagos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ciprofloxacin (CPX) is prone to spontaneous self-aggregation and formation of supramolecular dimers (π - π stacking) due to its complicated surface chemistry which has been associated with its anomalous solubility and instability in aqueous systems particularly near neutral pH. The surface characteristic of ciprofloxacin was modified through non-intuitive counterion interaction between CPX and diethylaminoethyl dextran (DDEX) to form nanoconjugate assembly. The CPX-DDEX nanoconjugate was confirmed by FTIR, SEM, DSC, TGA, and

Indexed as

CiprofloxacinNanoconjugatesDrug CarriersIbuprofenPolymersSuspensionsCiprofloxacinDrug CarriersIbuprofenNanoconjugatesPolymersSuspensionsciprofloxacin molecular stackingdiethylaminoethyl dextranin vitro drug release kineticsnanoconjugate suspensionnon-intuitive behaviorsedimentation volume

Identifiers

PMID34467444
OpenAlexW3198161593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.