Evidence map›Paper›PMID 34467399›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Extended Frontal Networks for Visual and Auditory Working Memory.

Abigail L Noyce, Ray W Lefco, James A Brissenden, Sean M Tobyne, Barbara G Shinn-Cunningham, David C Somers

Open access · greenAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  4. Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.Movement disorders : official journal of the Movement Disorder Society · 2026
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  11. Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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  19. Human striatal association megaclusters.Journal of neurophysiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Abigail L NoyceNeuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Ray W LefcoGraduate Program in Neuroscience, Boston University, Boston, MA 02215, USA.
James A BrissendenDepartment of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA.
Sean M TobyneGraduate Program in Neuroscience, Boston University, Boston, MA 02215, USA.
Barbara G Shinn-CunninghamNeuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
David C SomersDepartment of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA.
Boston University · USCarnegie Mellon University · US

Funding

Human Fronto-Parietal Networks for Visual Attention and MemoryR01EY022229 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SOMERS, DAVID C · 2012 to 2016
$2.0M
Functional Fractionation of Attentional Networks in Human CerebellumR21EY027703 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SOMERS, DAVID C · 2017 to 2018
$471k
Multiplexed Frontal Cortex Organization for Flexibility in Short-Term MemoryF32EY026796 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI NOYCE, ABIGAIL L. · 2016 to 2018
$146k
Predicting Whole Brain Multi-Sensory Cognitive Control Networks: Relationship with Neuropsychological Test Performance and Repetitive Head ImpactF31NS103306 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI TOBYNE, SEAN MICHAEL · 2017 to 2018
$61k
NEI NIH HHS F32 EY026796NEI NIH HHS R01 EY022229NEI NIH HHS R21 EY027703NINDS NIH HHS F31 NS103306
6 · The paper itself

Abstract

Working memory (WM) supports the persistent representation of transient sensory information. Visual and auditory stimuli place different demands on WM and recruit different brain networks. Separate auditory- and visual-biased WM networks extend into the frontal lobes, but several challenges confront attempts to parcellate human frontal cortex, including fine-grained organization and between-subject variability. Here, we use differential intrinsic functional connectivity from 2 visual-biased and 2 auditory-biased frontal structures to identify additional candidate sensory-biased regions in frontal cortex. We then examine direct contrasts of task functional magnetic resonance imaging during visual versus auditory 2-back WM to validate those candidate regions. Three visual-biased and 5 auditory-biased regions are robustly activated bilaterally in the frontal lobes of individual subjects (N = 14, 7 women). These regions exhibit a sensory preference during passive exposure to task stimuli, and that preference is stronger during WM. Hierarchical clustering analysis of intrinsic connectivity among novel and previously identified bilateral sensory-biased regions confirms that they functionally segregate into visual and auditory networks, even though the networks are anatomically interdigitated. We also observe that the frontotemporal auditory WM network is highly selective and exhibits strong functional connectivity to structures serving non-WM functions, while the frontoparietal visual WM network hierarchically merges into the multiple-demand cognitive system.

Indexed as

Auditory PerceptionMemory, Short-TermBrain MappingFemaleFrontal LobeHumansMagnetic Resonance ImagingattentionfMRIfrontal cortexfunctional connectivitymultisensory

Identifiers

PMID34467399
PMCPMC8841551
OpenAlexW3196309890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.