Evidence map›Paper›PMID 34467279›Full record

ArticleJACS Au2021

Ganglioside GM3 Analogues Containing Monofluoromethylene-Linked Sialoside: Synthesis, Stereochemical Effects, Conformational Behavior, and Biological Activities.

Go Hirai, Marie Kato, Hiroyuki Koshino, Eri Nishizawa, Kana Oonuma, Eisuke Ota, Toru Watanabe, Daisuke Hashizume, Yuki Tamura, Mitsuaki Okada and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Go HiraiGraduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.ORCID 0000-0003-3420-555X
Marie KatoRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Hiroyuki KoshinoRIKEN Center for Sustainable Resource Science, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Eri NishizawaRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Kana OonumaRIKEN Center for Sustainable Resource Science, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Eisuke OtaRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Toru WatanabeRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Daisuke HashizumeRIKEN Center for Emergent Matter Science, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.ORCID 0000-0001-7152-4408
Yuki TamuraRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Mitsuaki OkadaRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
Taeko MiyagiMiyagi Cancer Center Research Institute, Natori 981-1293, Japan.
Mikiko SodeokaRIKEN Cluster for Pioneering Resaerch, Synthetic Organic Chemistry Laboratory, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.ORCID 0000-0002-1344-364X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycoconjugates are an important class of biomolecules that regulate numerous biological events in cells. However, these complex, medium-size molecules are metabolically unstable, which hampers detailed investigations of their functions as well as their potential application as pharmaceuticals. Here we report sialidase-resistant analogues of ganglioside GM3 containing a monofluoromethylene linkage instead of the native

Identifiers

PMID34467279
PMCPMC8395706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.