Evidence map›Paper›PMID 34467250›Full record

ArticleCell reports. Medicine2021

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments.

Sarang S Talwelkar, Mikko I Mäyränpää, Lars Søraas, Swapnil Potdar, Jie Bao, Annabrita Hemmes, Nora Linnavirta, Jon Lømo, Jari Räsänen, Aija Knuuttila and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Sarang S TalwelkarInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Mikko I MäyränpääHUSLAB, Division of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki 00029, Finland.
Lars SøraasPontoppidans Gate 9B, 0462 Oslo, Norway.
Swapnil PotdarInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Jie BaoInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Annabrita HemmesInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Nora LinnavirtaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Jon LømoDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Jari RäsänenDepartment of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Aija KnuuttilaDepartment of Pulmonary Medicine, Heart and Lung Center, and Cancer Center, Helsinki University Hospital, Helsinki, Finland.
Krister WennerbergInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Emmy W VerschurenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
University of Helsinki · FIHelsinki University Hospital · FIOslo University Hospital · NOUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional profiling of a cancer patient's tumor cells holds potential to tailor personalized cancer treatment. Here, we report the utility of fresh uncultured tumor-derived EpCAM

Indexed as

Precision MedicineAdenocarcinoma of LungAdultAgedAnimalsCarcinoma, Non-Small-Cell LungCellular ReprogrammingEpithelial CellsFemaleHumansLung NeoplasmsMaleMiceMiddle AgedMolecular Targeted TherapyProto-Oncogene Proteins p21(ras)KRAS protein, humanProto-Oncogene Proteins p21(ras)ALKdrug sensitivity and resistance testingEGFRex vivo drug screeningfunctional diagnosticsKRASlung cancerpersonalized medicinepharmacogenomicstargeted therapy

Identifiers

PMID34467250
PMCPMC8385325
OpenAlexW3124786886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.