Evidence map›Paper›PMID 34467249›Full record

ArticleCell reports. Medicine2021

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice.

Arshad Khan, Ekramy E Sayedahmed, Vipul K Singh, Abhishek Mishra, Stephanie Dorta-Estremera, Sita Nookala, David H Canaday, Min Chen, Jin Wang, K Jagannadha Sastry and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Developing the next-generation of adenoviral vector vaccines.Human vaccines & immunotherapeutics · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Mucosal immunotherapy targeting APC in lung disease.Journal of inflammation (London, England) · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. TheFrontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Arshad KhanDepartment of Pathology and Genomic Medicine, Houston Methodist Academic Institute, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX, USA.
Ekramy E SayedahmedDepartment of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology, and Infectious Disease, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Vipul K SinghDepartment of Pathology and Genomic Medicine, Houston Methodist Academic Institute, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX, USA.
Abhishek MishraDepartment of Pathology and Genomic Medicine, Houston Methodist Academic Institute, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX, USA.
Stephanie Dorta-EstremeraDepartment of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Sita NookalaDepartment of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
David H CanadayDepartment of Medicine, Case Western Reserve University and Cleveland Veterans Affairs, Cleveland, OH, USA.
Min ChenDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Jin WangImmunobiology and Transplant Science Center, Houston Methodist Research Institute, and Department of Surgery, Weill Cornell Medical College, Houston, TX, USA.
K Jagannadha SastryDepartment of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Suresh K MittalDepartment of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology, and Infectious Disease, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Chinnaswamy JagannathDepartment of Pathology and Genomic Medicine, Houston Methodist Academic Institute, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX, USA.
Houston Methodist · USThe University of Texas MD Anderson Cancer Center · USPurdue University West Lafayette · USBaylor College of Medicine · USCase Western Reserve University · USCornell University · US

Funding

Molecular Regulation of Long-term Immune MemoryR01AI123221 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, JIN · 2016 to 2020
$2.0M
MOLECULAR REGULATION OF IMMUNITY TO VIRAL INFECTIONSR01AI116644 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, JIN · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI116644NIAID NIH HHS R01 AI123221
6 · The paper itself

Abstract

Although the BCG vaccine offers partial protection, tuberculosis remains a leading cause of infectious disease death, killing ∼1.5 million people annually. We developed mucosal vaccines expressing the autophagy-inducing peptide C5 and mycobacterial Ag85B-p25 epitope using replication-defective human adenovirus (HAdv

Indexed as

AdenoviridaeAnimalsAntigens, BacterialAutophagosomesBCG VaccineCathepsinsCattleCytokinesDendritic CellsDNA ReplicationFemaleGalectinsGenetic VectorsHumansImmunologic MemoryLysosomesAntigens, BacterialBCG VaccineCathepsinsCytokinesGalectinsTuberculosis VaccinesVaccines, Syntheticantigen presentationautophagyBAdvBCG vaccinebovine adenovirusC57BL/6 micedendritic cellsgalectin-3/8HAdvhuman adenovirusmucosal vaccineMycobacterium tuberculosis

Identifiers

PMID34467249
PMCPMC8385328
OpenAlexW3195133163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.