Evidence map›Paper›PMID 34467228›Full record

ArticleSTAR protocols2021

Protocol for remapping of place cells in disease mouse models.

Heechul Jun, Jasmine Chavez, Allen Bramian, Kei M Igarashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heechul JunDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
Jasmine ChavezDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
Allen BramianDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
Kei M IgarashiDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
University of California, Irvine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Understanding neural circuits for associative memory in the lateral entorhinal cortexR01MH121736 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$2.3M
Cell-type-specific vulnerability of the entorhinal cortex in Alzheimer's diseaseR01AG066806 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2020 to 2024
$2.0M
Understanding the role of gamma oscillations underlying entorhinal cortex dysfunction in Alzheimer’s diseaseR01AG063864 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$1.9M
Investigating spatial representation in hippocampal entorhinal circuit of knock in Alzheimer's modelF31AG069500 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JUN, HEECHUL · 2020 to 2021
$75k
NIA NIH HHS F31 AG069500NIA NIH HHS R01 AG063864NIA NIH HHS R01 AG066806NIGMS NIH HHS T32 GM008620NIMH NIH HHS R01 MH121736
6 · The paper itself

Abstract

Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called "remapping," and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's disease. Here, we describe our protocol for investigating remapping of place cells and grid cells using a custom-made electrophysiology device, with detailed descriptions and problem-solving tips for the construction and implantation of the recording device. We also provide steps for behavioral training, recording, and data analysis. For complete details on the use and execution of this protocol, please refer to Jun et al. (2020).

Indexed as

Disease Models, AnimalAnimalsBehavior, AnimalCA1 Region, HippocampalCraniotomyElectrodes, ImplantedElectrophysiologyFemaleHippocampusMaleMiceMice, Inbred C57BLBehaviorModel OrganismsNeuroscience

Identifiers

PMID34467228
PMCPMC8384906
OpenAlexW3194680228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.