Evidence map›Paper›PMID 34467220›Full record

ArticleCurrent research in toxicology2021

Reproducibility and robustness of high-throughput S1500+ transcriptomics on primary rat hepatocytes for chemical-induced hepatotoxicity assessment.

Fan Lee, Imran Shah, Yun Ting Soong, Jiangwa Xing, Inn Chuan Ng, Farah Tasnim, Hanry Yu

Abstract read
In one paragraph

Article in Current research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. From vision toward best practices: EvaluatingFrontiers in toxicology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fan LeeInnovations in Food & Chemical Safety Program (IFCS), Institute of Bioengineering and Bioimaging (IBB), Agency for Science Technology and Research, Singapore.
Imran ShahCenter for Computational Toxicology & Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Yun Ting SoongInnovations in Food & Chemical Safety Program (IFCS), Institute of Bioengineering and Bioimaging (IBB), Agency for Science Technology and Research, Singapore.
Jiangwa XingInnovations in Food & Chemical Safety Program (IFCS), Institute of Bioengineering and Bioimaging (IBB), Agency for Science Technology and Research, Singapore.
Inn Chuan NgDepartment of Physiology and Mechanobiology Institute, National University of Singapore, Singapore.
Farah TasnimInnovations in Food & Chemical Safety Program (IFCS), Institute of Bioengineering and Bioimaging (IBB), Agency for Science Technology and Research, Singapore.
Hanry YuInnovations in Food & Chemical Safety Program (IFCS), Institute of Bioengineering and Bioimaging (IBB), Agency for Science Technology and Research, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-based

Indexed as

Collagen sandwichConnectivity mappingGene set enrichment analysisHallmark gene set collectionHepatotoxicityHigh-throughput transcriptomicsRat hepatocytesS1500+ gene setTempO-Seq

Identifiers

PMID34467220
PMCPMC8384775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.