Evidence map›Paper›PMID 34466798›Full record

ArticleMetabolism open2021

Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of

Akeberegn Gorems Ayele, Prem Kumar, Ephrem Engidawork

Open access · goldAbstract read
In one paragraph

Article in Metabolism open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Antidiabetic potential of polysaccharides from Algerian SaharanTurkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  2. Antihyperglycemic Potential of Dried Powder Combination ofJournal of pharmacy & bioallied sciences · 2024
    Article
  3. Evaluations of theMetabolism open · 2024
    Article
  4. Characterization ofPreventive nutrition and food science · 2024
    Article
  5. DecipheringAdvances in pharmacological and pharmaceutical sciences · 2024
    Article
  6. Review
  7. Article
  8. Metabolism open · 2022
    Article
  9. Review
  10. Article
  11. Antidiabetic Activity of Hydromethanolic Extract of CrudeJournal of experimental pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Akeberegn Gorems AyeleDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Prem KumarDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Ephrem EngidaworkDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Addis Ababa University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of diabetes mellitus is on the inexorable rise despite the promises of a wide range of conventional medications. Thus, there is a need to scientifically investigate plants for antidiabetic effect.

methodsAfter the

resultsAcute toxicity study showed the extract is safe with ≥2 g/kg. The

conclusionThe findings collectively indicate that the extract has an antidiabetic activity, with low risk of hypoglycemia, probably mediated by various secondary metabolites that act in synergy.

Indexed as

BGL, blood glucose levelDiabetes mellitusDM, Diabetes mellitusDNS, Dinitrosalicylic acidDPPH, diphenyl-1-picrylhydrazineFBG, Fasting blood glucoseGAE, Gallic acid equivalent weightIn vitroIn vivoIP, intraperitonealNO, nitric oxideOGTT, Oral glucose toleranceRubus erlangeriStreptozotocinSTZ, StreptozotocinTFC, Total flavonoid content

Identifiers

PMID34466798
PMCPMC8384911
OpenAlexW3196276176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.