Evidence map›Paper›PMID 34466750›Full record

ArticleJACC. Basic to translational science2021

Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury.

Denise Veltman, Ming Wu, Peter Pokreisz, Piet Claus, Hilde Gillijns, Ellen Caluwé, Maarten Vanhaverbeke, Willy Gsell, Uwe Himmelreich, Peter R Sinnaeve and 1 more

Abstract read
In one paragraph

Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denise VeltmanDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Ming WuDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Peter PokreiszDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Piet ClausDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Hilde GillijnsDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Ellen CaluwéDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Maarten VanhaverbekeDepartment of Cardiovascular Diseases, University Hospital Leuven, Leuven, Belgium.
Willy GsellDepartment of Imaging and Pathology, Biomedical MRI, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Uwe HimmelreichDepartment of Imaging and Pathology, Biomedical MRI, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Peter R SinnaeveDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Stefan P JanssensDepartment of Cardiovascular Sciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bacterial C-type lectin domain family 4 member E (CLEC4E) has an important role in sterile inflammation, but its role in myocardial repair is unknown. Using complementary approaches in porcine, murine, and human samples, we show that

Indexed as

ACS, acute coronary syndromeAMI, acute myocardial infarctionANOVA, analysis of varianceCAD, coronary artery diseaseCar3, carbonic anhydrase 3CLEC4ECLEC4E, C-type lectin domain family 4 member ECMC, cardiac myocyteCxcl2, CXC chemokine ligand 2Cxcr2, CXC chemokine receptor 2DAMP, damage-associated molecular patternECM, extracellular matrixEfna2, ephrin A2ESV, end-systolic volumeGrk2, G protein–coupled receptor kinase 2hs-TnI, high-sensitivity troponin IinflammationI/R, ischemia-reperfusionischemia-reperfusion injuryLAD, left anterior descending coronary arteryLV, left ventricularmagnetic resonance imagingMPO, myeloperoxidaseMRI, magnetic resonance imagingmyocardial remodelingNS, not significantPRR, pattern recognition receptorqRT-PCR, quantitative reverse transcription polymerase chain reactionRNA, ribonucleic acidSMC, smooth muscle cellSTEMI, ST-segment elevation myocardial infarctionTnT, troponin TWT, wild-type

Identifiers

PMID34466750
PMCPMC8385568

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.