ReviewBioactive materials2022
Factors influencing the drug release from calcium phosphate cements.
Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
- Dipyridamole-Coated 3D-Printed β-Tricalcium Phosphate Scaffolds: Spectrophotometric Characterization, Drug Release Kinetics, and In Vitro Evaluation to Guide Critical-Sized Bone Defect Repair Studies.Journal of functional biomaterials · 2026Article
- Design and Development of a Bioink for Fabricating Crosslinked Hydrogel Microneedles via 3D Printing for Transdermal Delivery of Estradiol Nanoparticles.Pharmaceutics · 2026Article
- Injectable living hydrogel as engineered biotherapeutic to promote tooth-extraction wound healing and alveolar bone regeneration.Bioactive materials · 2026Article
- Folic acid-functionalized mesoporous silica nanoparticles integrating fluorouracil-derived carbon dots and porphyrin for targeted breast cancer chemo-photodynamic therapy.RSC advances · 2026Article
- Injectable and In Situ Hydration-Reinforced Hybrid Bone Cements for Accelerated Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sialic acid-guided spatiotemporal hydrogel therapy for liver cancer.Materials today. Bio · 2026Article
- Article
- Advances in Periodontal Therapy: A Comprehensive Review ofCurrent drug discovery technologies · 2026Review
- Particle-Size-Determined Crystallization and Dissolution Behavior of Amorphous Griseofulvin.Pharmaceutical research · 2026Article
- Metal-Organic Framework-Based Antimicrobial Touch Surfaces to Prevent Cross-Contamination.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Synergistic effects of bioactive glass and sodium alginate on the surface properties and therapeutic release of ciprofloxacin from apatite cements.International journal of pharmaceutics: X · 2025Article
- Point-of-care bone cement based on natural peptide comonomer protects orthopaedic implants from bacterial challenge.Materials today. Bio · 2025Article
- Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures.Bioactive materials · 2025Article
- High-efficiency atmospheric water harvesting enabled by ultrasonic extraction.Nature communications · 2025Article
- β-Cyclodextrin Inclusion Complexes of Curcumin and Synthetic Analogues in PVA/Carrageenan Hydrogels: A Platform for Sustained Release and Microbial Control.Gels (Basel, Switzerland) · 2025Article
- A Chrono-Prolific Controlled Release Tripartite Tablet: Case Study of Paracetamol, Diclofenac Sodium and Esomeprazole Magnesium Trihydrate.AAPS PharmSciTech · 2025Article
- Formulation and Structural Optimisation of PVA-Fibre Biopolymer Composites for 3D Printing in Drug Delivery Applications.Polymers · 2025Article
- Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery.Gels (Basel, Switzerland) · 2025Article
- Antibiofilm Activity of a Novel Calcium Phosphate Cement Doped with Two Antibiotics.Journal of functional biomaterials · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thanks to their biocompatibility, biodegradability, injectability and self-setting properties, calcium phosphate cements (CPCs) have been the most economical and effective biomaterials of choice for use as bone void fillers. They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone, including primarily antibiotics and growth factors. This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years. The chemical, compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed. In doing so, the effects of (i) the chemistry of the matrix, (ii) porosity, (iii) additives, (iv) drug types, (v) drug concentrations, (vi) drug loading methods and (vii) release media have been distinguished and discussed individually. Kinetic specificities of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.