Evidence map›Paper›PMID 34466721›Full record

ArticleBioactive materials2022

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy.

Nil Kanatha Pandey, Wei Xiong, Lingyun Wang, Wei Chen, Brian Bui, Jian Yang, Eric Amador, Mingli Chen, Christina Xing, Aseem Atul Athavale and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  7. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
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  11. Article
  12. Interlayer Electrons Polarization of Asymmetric Metal Nanoclusters/g-CAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Nil Kanatha PandeyDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Wei XiongKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Lingyun WangDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Wei ChenDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Brian BuiDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Jian YangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Eric AmadorDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Mingli ChenDepartment of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110819, China.
Christina XingDepartment of Physics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Aseem Atul AthavaleDepartment of Materials Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.
Yaowu HaoDepartment of Materials Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.
Wirya FeiziDepartment of Physics, The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
Lloyd LumataDepartment of Physics, The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
The University of Texas at Arlington · USThe University of Texas at Dallas · USNortheastern University · CNPennsylvania State University · USSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggregation-induced emission luminogens (AIEgens) exhibit efficient cytotoxic reactive oxygen species (ROS) generation capability and unique light-up features in the aggregated state, which have been well explored in image-guided photodynamic therapy (PDT). However, the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications. Coincidentally, microwaves (MWs) show a distinct advantage for deeper penetration depth in tissues than light. Herein, for the first time, we report AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment. We found that two AIEgens (

Indexed as

AIEgensCancer treatmentMicrowave ablationMicrowavesPhotodynamic therapyReactive oxygen speciesSinglet oxygen

Identifiers

PMID34466721
PMCPMC8379457
OpenAlexW3172585342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.