Evidence map›Paper›PMID 34466711›Full record

ArticleContemporary clinical trials communications2021

Study protocol for a two-center test of a nurse-implemented chronotherapeutic restoring bundle in critically ill children: RESTORE Resilience (R

Mallory A Perry, Onella S Dawkins-Henry, Ronke E Awojoodu, Jennifer Blumenthal, Lisa A Asaro, David Wypij, Sapna R Kudchadkar, Athena F Zuppa, Martha A Q Curley

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04695392 (Restore Resilience in Critically Ill Children), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04695392 nacompletednot on this map

Restore Resilience in Critically Ill Children

TypeinterventionalSponsorUniversity of PennsylvaniaRan2017 to 2021Enrolled56ConditionsAcute Respiratory Distress SyndromeArmsR2 Bundle
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mallory A PerryResearch Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Onella S Dawkins-HenryDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Ronke E AwojooduDepartment of Anesthesiology and Critical Care Medicine, Charlotte R. Bloomberg Children's Center, Johns Hopkins Medicine, Baltimore, MD, USA.
Jennifer BlumenthalResearch Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lisa A AsaroDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
David WypijDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Sapna R KudchadkarDepartment of Anesthesiology and Critical Care Medicine, Charlotte R. Bloomberg Children's Center, Johns Hopkins Medicine, Baltimore, MD, USA.
Athena F ZuppaDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Martha A Q CurleyResearch Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Protein Optimization with Exercise to Improve Muscle Mass and Functional Outcomes (PROXIMUS)R01DK132348 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KUDCHADKAR, SAPNA R, MEHTA, NILESH M · 2022 to 2024
$1.0M
RESTORE resilience in critically ill children - R2R21HD093369 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI CURLEY, MARTHA AQ, KUDCHADKAR, SAPNA R · 2017 to 2018
$506k
NICHD NIH HHS R21 HD093369NIDDK NIH HHS R01 DK132348
6 · The paper itself

Abstract

Often, pediatric intensive care environments are not conducive to healing the sick. Critically ill children experience disruptions in their circadian rhythms, which can contribute to delayed recovery and poor outcomes. We aim to test the hypothesis that children managed via CLINICALTRIALSGOV IDENTIFIER: NCT04695392.

Indexed as

CINC, continuity in nursing careCircadian rhythmDARE, daytime activity ratio estimateDCC, Data Coordinating CenterDMS, data management systemEEG, electroencephalographyFCCS, Family-Centered Care ScaleICU, intensive care unitMechanical ventilationNurse-implemented interventionsPCPC, Pediatric Cerebral Performance CategoryPediatric critical carePICU, pediatric intensive care unitPOPC, Pediatric Overall Performance CategoryPRISM III-12, Pediatric Risk of Mortality III score from first 12 h in the PICUWAT-1, Withdrawal Assessment Tool-1

Identifiers

PMID34466711
PMCPMC8385396

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.