ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2021
Low crude protein diets supplemented with casein hydrolysate enhance the intestinal barrier function and decrease the pro-inflammatory cytokine expression in the small intestine of pigs.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Carbohydrate and protein adaptation in low-protein diets for livestock and poultry: a nutritional revolution from static balance to dynamic synergy.Journal of animal science and biotechnology · 2026Review
- The protective role of a moderate protein diet in ETEC-infected piglets: Optimization of growth, immunity, and microbial balance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Disadvantages of the Use of Low-Protein Diets in Weaned Piglets and Nutritional Interventions: A Meta-Analysis.Animals : an open access journal from MDPI · 2026Review
- Soy Protein and Safflower-Seed Oil Attenuate Inflammation and Immune Dysfunction in Rats with Hyperuricemia.International journal of molecular sciences · 2024Article
- Review
- Anti-inflammatory potential of casein enzymatic hydrolysate/gelatin methacryloyl scaffolds for vital pulp therapy.Clinical oral investigations · 2024Article
- Addition of Spray-Dried Plasma in Phase 2 Diets for Weanling Pigs Improves Growth Performance, Reduces Diarrhea Incidence, and Decreases Mucosal Pro-Inflammatory Cytokines.Animals : an open access journal from MDPI · 2024Article
- The application of protease in aquaculture: Prospects for enhancing the aquafeed industry.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Effects of dietary protein level on intestinal function and inflammation in nursery pigs.Journal of animal science · 2024Article
- Comparison between Organic and Inorganic Zinc Forms and Their Combinations with Various Dietary Fibers in Respect of the Effects on Electrolyte Concentrations and Mucosa in the Large Intestine of Pigs.International journal of molecular sciences · 2023Article
- Low Protein Diets Supplemented With Alpha-Ketoglutarate Enhance the Growth Performance, Immune Response, and Intestinal Health in Common Carp (Frontiers in immunology · 2022Article
- Dietary Crude Protein Levels Alter Diarrhea Incidence, Immunity, and Intestinal Barrier Function of Huanjiang Mini-Pigs During Different Growth Stages.Frontiers in immunology · 2022Article
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Authors and funding
6 authors.
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Abstract
To reduce nitrogen excretion and lower feeding costs, low crude protein (CP) diets are sometimes proposed, however, a great reduction of dietary CP concentration (>4% reduction vs. recommended concentration), even supplemented with essential and nonessential amino acids (AA) can detrimentally affect small intestinal barrier function and immunity, possibly due to the excessive lack of peptides. Here we hypothesize that with an extremely low CP concentration diet, protein-derived peptides, rather than AA supplementation, can improve intestinal barrier development and health. To test this hypothesis, 21 growing pigs (19.90 ± 1.00 kg body weight) were randomly assigned to 3 treatments with control diet (16% CP), or low CP diets (13% CP) supplemented with AA (LCPA) or casein hydrolysate (LCPC) for 28 days. In comparison with the control diet, the LCPA diet decreased the protein expression level of jejunal barrier factor zonula occludens-1 (ZO-1) and stem cell proliferation factor leucine-rich repeat-containing G-protein-coupled receptor-5, whereas the LCPC diet enhanced intestinal barrier function by increasing the protein expression level of jejunal occludin and ZO-1 and ileal mucin-2. The LCPA diet reduced
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