Evidence map›Paper›PMID 34466662›Full record

ArticleTrauma surgery & acute care open2021

Acute appendicitis severity during the early COVID-19 pandemic period.

Thomas D Zaikos, Elizabeth M Boudiab, Emanuela C Peshel, Annie A Wu, Ethan Dyer, Elliott R Haut, Kevan J Salimian

Open access · goldAbstract read
In one paragraph

Article in Trauma surgery & acute care open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Thomas D ZaikosDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-3055-2810
Elizabeth M BoudiabDepartment of General Surgery, Beaumont Health, Royal Oak, Michigan, USA.
Emanuela C PeshelDepartment of General Surgery, Beaumont Health, Royal Oak, Michigan, USA.
Annie A WuSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Ethan DyerSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Elliott R HautDivsion of Acute Care Surgery, Department of Surgery, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-7075-771X
Kevan J SalimianDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-7251-1916
Johns Hopkins University · USBeaumont Health · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

backgroundThe early COVID-19 pandemic period significantly strained the US healthcare system. During this period, consultations and admissions for acute medical conditions decreased, which was associated with an increase in disease-specific morbidity and mortality. Therefore, we sought to determine what, if any, effect the early COVID-19 pandemic period had on the presentation, management, and histopathologic severity of acute appendicitis.

methodsWe performed a retrospective, observational study to compare the frequencies with which patients presented with acute appendicitis, the proportion of whom were managed surgically, and the distribution of histopathologic disease severity among all resected appendix specimens during the early COVID-19 pandemic period (March 6-June 30, 2020) to equivalent time periods for the 3 preceding/pre-pandemic years (2017-2019).

resultsCompared with equivalent pre-pandemic time periods, during the COVID-19 pandemic period there was no significant difference in the number of patients who presented for acute appendicitis, there was a decreased rate of surgical management (81% vs 94%; p=0.014), and there was an overall increase in the incidence of perforated appendicitis (31% vs 16%; p=0.004), including by histopathologic diagnosis (25% vs 11%; p=0.01). DISCUSSION: Despite potential patient hesitancy to present for care, the early COVID-19 pandemic period was associated with no significant change in the number of patients presenting with acute appendicitis; however, there was a significant increase in the incidence of perforated appendicitis. This study highlights the need to encourage patients to avoid late presentation for acute surgical conditions and for the robust planning for the medical management of otherwise surgical abnormalities during episodes of restricted or limited resources. LEVEL OF EVIDENCE: Level III.

Indexed as

appendectomyappendicitisCOVID-19

Identifiers

PMID34466662
PMCPMC8392736
OpenAlexW3193737334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.