ArticleACS central science2021
Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity.
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Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Chemical and Biological Determinants of PEG-Lipid Shedding From Therapeutic Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- PEG-lipid shedding and biodistribution are shaped by nanocarrier morphology and lipid chemistry.Cell biomaterials · 2026Article
- Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics.Nature biomedical engineering · 2026Article
- Fabrication of RIG-I-Activating Nanoparticles for Intratumoral Immunotherapy via Flash Nanoprecipitation.Molecular pharmaceutics · 2025Article
- Cell-Free Expression of Nipah Virus Transmembrane Proteins for Proteoliposome Vaccine Design.ACS nano · 2025Article
- Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses.Matter · 2025Article
- The Role of Structural Flexibility in Hydrocarbon-Stapled Peptides Designed to Block Viral Infection via Human ACE2 Mimicry.Peptide science (Hoboken, N.J.) · 2024Article
- Therapeutic synthetic and natural materials for immunoengineering.Chemical Society reviews · 2024Review
- Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications.Materials (Basel, Switzerland) · 2024Review
- Article
- Detection of SARS-CoV-2 Based on Nucleic Acid Amplification Tests (NAATs) and Its Integration into Nanomedicine and Microfluidic Devices as Point-of-Care Testing (POCT).International journal of molecular sciences · 2023Review
- Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers.ACS chemical biology · 2022Article
- Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccines.iScience · 2022Article
- Polymerized porin as a novel delivery platform for coronavirus vaccine.Journal of nanobiotechnology · 2022Article
- DENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue Vaccine.Pharmaceutics · 2022Article
- Polymer-Based Nanosystems-A Versatile Delivery Approach.Materials (Basel, Switzerland) · 2021Review
- Bimodal Targeting of Human Leukocytes by Fc- and CpG-Decorated Polymersomes to Tune Immune Induction.Biomacromolecules · 2021Article
- The pivotal roles of the host immune response in the fine-tuning the infection and the development of the vaccines for SARS-CoV-2.Human vaccines & immunotherapeutics · 2021Article
- Unleashing the potential of cell membrane-based nanoparticles for COVID-19 treatment and vaccination.Expert opinion on drug delivery · 2021Article
- Effect of SARS-CoV-2 Mutations on the Efficacy of Antibody Therapy and Response to Vaccines.Vaccines · 2021Review
Corrections and comments
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Authors and funding
30 authors.
Lisa R VolpattiPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0001-6197-0703
Rachel P WallacePritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Shijie CaoPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0002-9175-0813
Michal M RaczyPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Ruyi WangPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Laura T GrayPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Aaron T AlparPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Priscilla S BriquezPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Nikolaos MitrousisPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Tiffany M MarchellCommittee on Immunology, University of Chicago, Chicago, Illinois 60637, United States.
Maria Stella SassoPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Mindy NguyenPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Aslan MansurovPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Erica BudinaPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Ani SolankiAnimal Resources Center, University of Chicago, Chicago, Illinois 60637, United States.
Elyse A WatkinsPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Mathew R SchnorenbergPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Andrew C TremainCommittee on Immunology, University of Chicago, Chicago, Illinois 60637, United States.
Joseph W RedaPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Vlad NicolaescuDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, Illinois 60637, United States.
Kevin FurlongDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, Illinois 60637, United States.
Steve DvorkinDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, Illinois 60637, United States.
Shann S YuPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Balaji ManicassamyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, United States.
James L LaBelleDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0001-6776-4695
Matthew V TirrellPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0001-6185-119X
Glenn RandallDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, Illinois 60637, United States.
Marcin KwissaPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Melody A SwartzPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.
Jeffrey A HubbellPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0003-0276-5456
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1MMEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MRESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MParadoxical roles of tumor lymphangiogenesis on tumor immunity and implications for immunotherapy - Resubmission 01R01CA219304 · NCI · UNIVERSITY OF CHICAGO · PI SWARTZ, MELODY ANN · 2018 to 2022
$1.8MA Potent and Specific Approach to Targeting B-Cell Lymphoma: Disrupting Malignant Protein-Protein Interactions Using CD19-Targeted Stapled Peptide Amphiphile NanoparticlesF30CA221250 · NCI · UNIVERSITY OF CHICAGO · PI SCHNORENBERG, MATHEW RYAN · 2017 to 2021
$250kNCI NIH HHS F30 CA221250NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA219304NHLBI NIH HHS T32 HL007605NIAID NIH HHS HHSN272201400008CNIAID NIH HHS T32 AI007090NIGMS NIH HHS T32 GM007281
Abstract
The COVID-19 pandemic underscores the need for rapid, safe, and effective vaccines. In contrast to some traditional vaccines, nanoparticle-based subunit vaccines are particularly efficient in trafficking antigens to lymph nodes, where they induce potent immune cell activation. Here, we developed a strategy to decorate the surface of oxidation-sensitive polymersomes with multiple copies of the SARS-CoV-2 spike protein receptor-binding domain (RBD) to mimic the physical form of a virus particle. We evaluated the vaccination efficacy of these surface-decorated polymersomes (RBD
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