Evidence map›Paper›PMID 34466573›Full record

ArticleGalen medical journal2020

Construction of A Synthetic Gene Encoding the Multi-Epitope of

Maryam Karimi, Seyyed Javad Seyyed Tabaei, Mohammad Mehdi Ranjbar, Fardin Fathi, Ali Jalili, Ghasem Zamini, Amirreza Javadi Mamaghani, Javad Nazari, Daem Roshani, Nooshin Bagherani and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Galen medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Toxoplasma gondii vaccine candidates: a concise review.Irish journal of medical science · 2023
    Review
  3. Article
  4. Mining the Proteome ofAnimals : an open access journal from MDPI · 2022
    Review
  5. Article
  6. Diagnosis ofIranian journal of parasitology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Maryam KarimiStudent Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Seyyed Javad Seyyed TabaeiDepartment of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Mehdi RanjbarRazi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.
Fardin FathiCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Science, Sanandaj, Iran.
Ali JaliliCancer and Immunology Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Ghasem ZaminiDepartment of Parasitology and Mycology, Faculty of Medicine, Kurdistan University of Medical Science.
Amirreza Javadi MamaghaniDepartment of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Javad NazariMedical Department, Arak University of Medical Science, Arak, Iran.
Daem RoshaniSocial Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Nooshin BagheraniDepartment of Molecular Medicine, School of Advanced Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Bagher KhademerfanCellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Kurdistan University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRArak University of Medical Sciences · IRRazi Vaccine and Serum Research Institute · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMATERIALS AND

methodsA 3D structure of proteins was predicted by I-TASSER server, and linear and conformational B cell and T cell epitopes were predicted using the online servers. Then, the predicted epitopes were constructed and called Toxoeb, and their expression in the prokaryotic and eukaryotic cells was demonstrated using SDS-PAGE. In the next step, Western blotting with pooled sera of mice infected with

resultsThe current

conclusionOur constructed multi-epitope of

Indexed as

BioinformaticsDNA VaccineMulti-EpitopeToxoplasma gondii

Identifiers

PMID34466573
PMCPMC8343506
OpenAlexW3044967491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.