ArticleSchizophrenia research. Cognition2021
Network analysis of cognitive deficit in patients with schizophrenia spectrum disorders.
Article in Schizophrenia research. Cognition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring interrelationships between cognition, functioning and quality of life in schizophrenia spectrum disorders: a Bayesian analysis of networks.European archives of psychiatry and clinical neuroscience · 2026Article
- Russian‑Language Version of the Trail Making Test Implemented on the Inquisit Computer Platform.Sovremennye tekhnologii v meditsine · 2026Article
- Relationships between cognition and symptoms across mood and psychotic disorders.Psychiatry research · 2025Article
- Exploring the Interactions Between Psychotic Symptoms, Cognition, and Environmental Risk Factors: A Bayesian Analysis of Networks.Schizophrenia bulletin · 2025Article
- Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study.JMIR mental health · 2024Article
- Network dysfunction of sadness facial expression processing and morphometry in euthymic bipolar disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Empathy and Schizotypy: A Network Comparison of the Interpersonal Reactivity Index in High and Low Schizotypy Groups.Behavioral sciences (Basel, Switzerland) · 2024Article
- Article
- Article
- Elevated Anxious and Depressed Mood Relates to Future Executive Dysfunction in Older Adults: A Longitudinal Network Analysis of Psychopathology and Cognitive Functioning.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- The Relation between Negative Automatic Thoughts and Psychological Inflexibility in Schizophrenia.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairments are found in 80% of patients with schizophrenia. The severity of these impairments significantly affects the recovery of patients in terms of social functioning.Network analysis is the most suitable approach for studying complex relationships among cognitive functions.
aimTo build a network model of neurocognitive functions for identifying both the severity of impairments in individual functions and the vertices central to the whole model.
methodsThe study included 115 patients with schizophrenia and schizophrenia spectrum disorders and a comparison group, comprising 99 healthy subjects. The severity of clinical symptoms was assessed using the PANSS, CDSS and YMRS, and the SAS and BARS for extrapyramidal symptoms and akathisia. Subjects from the comparison group completed screening questionnaires QIDS-SR and PQ-16. Neurocognitive functions were assessed using the BACS.
resultsThe patients performed worse than the healthy subjects on all tests. In the cognitive network models of healthy subjects, fewer connections were revealed and the central place was occupied by working memory, the functioning of which depends upon everyday functioning in the community. In the cognitive models of patients there was a greater connectedness of neurocognitive functions. Furthermore, the central place of the networks in patients is occupied by the processing speed, evaluated primarily using the Symbol Coding test, which reflects the dependence of patient activity on lower-order functions.
conclusionThe processing speed deficit is key to schizophrenia and it may be considered a potential endophenotype of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.