Evidence map›Paper›PMID 34466275›Full record

ReviewBiomedical engineering letters2021

Technological advances in electrochemical biosensors for the detection of disease biomarkers.

Jae Hyun Kim, Young Joon Suh, Dongsung Park, Hyoju Yim, Hongrae Kim, Hye Jin Kim, Dae Sung Yoon, Kyo Seon Hwang

Abstract readReview
In one paragraph

Review in Biomedical engineering letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  3. Accumulation of heavy metals in the mycelium of Abortiporus biennis and their effect on oxalate oxidase activity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jae Hyun KimDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Young Joon SuhDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Dongsung ParkDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Hyoju YimDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Hongrae KimDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Hye Jin KimDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.
Dae Sung YoonSchool of Biomedical Engineering, Korea University, Seoul, 02841 Republic of Korea.
Kyo Seon HwangDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447 Republic of Korea.ORCID 0000-0003-3590-2074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With an increasing focus on health in contemporary society, interest in the diagnosis, treatment, and prevention of diseases has grown rapidly. Accordingly, the demand for biosensors for the early diagnosis of disease is increasing. However, the measurement range of existing electrochemical sensors is relatively high, which is not suitable for early disease diagnosis, requiring the detection of small amounts of biocomponents. Various attempts have been made to overcome this and amplify the signal, including binding with various labeling molecules, such as DNA, enzymes, nanoparticles, and carbon materials. Efforts are also being made to increase the sensitivity of electrochemical sensors, and the combination of nanomaterials, materials, and biotechnology offers the potential to increase sensitivity in a variety of ways. Recent studies suggest that electrochemical sensors can be a powerful tool in providing comprehensive insights into the targeting and detection of disease-associated biomarkers. Significant advances in nanomaterial and biomolecule approaches for improved sensitivity have resulted in the development of electrochemical biosensors capable of detecting multiple biomarkers in real time in clinically relevant samples. In this review, we have discussed the recent studies on electrochemical sensors for detection of diseases such as diabetes, degenerative diseases, and cancer. Further, we have highlighted new technologies to improve sensitivity using various materials, including DNA, enzymes, nanoparticles, and carbon materials.

Indexed as

BiomarkersDisease diagnosisEarly diagnosisElectrochemical biosensorsNanomaterials

Identifiers

PMID34466275
PMCPMC8396145

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.