ArticleClinical & translational immunology2021
Epigenetic programming underpins B-cell dysfunction in peanut and multi-food allergy.
Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer.Frontiers in immunology · 2026Pooled it
- Newborn blood DNA methylation and childhood asthma: findings from the ECHO program.International journal of epidemiology · 2025Pooled it
- Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.Scientific reports · 2022Trial
- Epigenetic insights into food allergy: The potential role of DNA methylation in diagnosis and management.The World Allergy Organization journal · 2026Review
- DNA methylation of food sensitization in a French-Canadian population.Clinical epigenetics · 2025Article
- Primate retroelement exonization and sexually dimorphicScience immunology · 2025Article
- New insights into the mechanisms of childhood food allergies.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Review
- Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.Frontiers in cell and developmental biology · 2025Article
- Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance.Frontiers in immunology · 2025Article
- Cord blood methylation at TNFRSF17 is associated with early allergic phenotypes.Immunologic research · 2024Article
- Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy.Cell & bioscience · 2024Review
- Epigenomic and epigenetic investigations of food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Review
- Multi-omics profiling approach in food allergy.The World Allergy Organization journal · 2023Review
- Multifood allergy: More than meets the eye.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Trained innate immunity, epigenetics, and food allergy.Frontiers in allergy · 2023Review
- The methylation profile ofFrontiers in immunology · 2023Article
- Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study.EClinicalMedicine · 2022Article
- Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans.Clinical & translational immunology · 2022Article
- Epigenetics in Food Allergy and Immunomodulation.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disruption of epigenetic profiles in various immune cell types in FA development. Recent data implicate B-cell dysfunction in FA; however, few studies have examined epigenetic changes within these cells.
methodsWe assessed epigenetic and transcriptomic profiles in purified B cells from adolescents with FA, comparing single-food-allergic (peanut only), multi-food-allergic (peanut and ≥1 other food) and non-allergic (control) individuals. Adolescents represent a phenotype of persistent and severe FA indicative of a common immune deviation.
resultsWe identified 144 differentially methylated probes (DMPs) and 116 differentially expressed genes (DEGs) that distinguish B cells of individuals with FA from controls, including differential methylation of the
conclusionOur data highlight epigenetic changes in B cells associated with peanut allergy, distinguishing features of the epigenome between single-food- and multi-food-allergic individuals and revealing differential developmental pathways potentially underpinning these distinct phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.