Evidence map›Paper›PMID 34466059›Full record

ArticleSaudi journal of biological sciences2021

Designing a highly immunogenic multi epitope based subunit vaccine against

Muhammad Asif Rasheed, Muhammad Awais, Adil Aldhahrani, Fayez Althobaiti, Alaa Alhazmi, Sobia Sattar, Umara Afzal, Hosam Ali Baeshen, Hesham Ali El Enshasy, Daniel Joe Dailin and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 4 countries.

Muhammad Asif RasheedDepartment of Biosciences, COMSATS University Islamabad, Sahiwal Campus, 57000 Sahiwal, Pakistan.
Muhammad AwaisDepartment of Biochemistry and Molecular Biology, Faculty of Science, University of Sialkot, Pakistan.
Adil AldhahraniClinical Laboratory Sciences Department, Turabah University College, Taif University, Taif 21995, Saudi Arabia.
Fayez AlthobaitiDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Alaa AlhazmiMedical Laboratory Technology Department, Jazan University, Jazan, Saudi Arabia.
Sobia SattarDepartment of Biosciences, COMSATS University Islamabad, Sahiwal Campus, 57000 Sahiwal, Pakistan.
Umara AfzalDepartment of Chemistry, Rawalpindi Women University, Satellite Town Rawalpindi, Pakistan.
Hosam Ali BaeshenDepartment of Orthodontics, Faculty of Dentistry, King Abdulaziz University, P. O. Box 80209, Jeddah 21589, Saudi Arabia.
Hesham Ali El EnshasyInstitute of Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Skudai, Johor, Malaysia.
Daniel Joe DailinInstitute of Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Skudai, Johor, Malaysia.
Ameena A Al-SurhaneeBiology Department, College of Science, Jouf University, Sakaka 2014, Kingdom of Saudi Arabia.
Faryal KabirUniversity Institute of Biochemistry and Biotechnology, PMAS-Arid Agriculture University, Rawalpindi, Pakistan.
COMSATS University Islamabad · PKTaif University · SACity of Scientific Research and Technological Applications · EGJazan University · SAJouf University · SAKing Abdulaziz University · SAPir Mehr Ali Shah Arid Agriculture University · PKRawalpindi Medical University · PKUniversity of SialkotUniversity of Technology Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSerious non-gastrointestinal-tract infections and food poisoning are caused by

methodsMultiple sequence alignment with the Clustal Omega method was used to identify conserved regions and Geneious Prime was used to produce a consensus sequence. T and B cell epitopes were predicted by various computational tools from the NetCTL and Immune Epitope Database (IEDB), respectively.

resultsAltogether, 6 HTL cells and 11 CTL epitopes were predicted. This vaccine's molecular docking is done with Patch Dock and LigPlot to verify interactions. The immune server (C-IMMSIM) was used to develop

conclusionWe designed universal vaccine against

Indexed as

Bacillus cereusBioinformaticsEpitope-based vaccineFood poisoningImmunity

Identifiers

PMID34466059
PMCPMC8381030
OpenAlexW3181639450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.