Evidence map›Paper›PMID 34466030›Full record

ArticleJournal of pain research2021

Suicide Attempts in US Veterans with Chronic Headache Disorders: A 10-Year Retrospective Cohort Study.

X Michelle Androulakis, Siyuan Guo, Jiajia Zhang, Jason Sico, Peter Warren, Alec Giakas, Xiaoming Li, B Lee Peterlin, Roy Mathew, Deborah Reyes

Open access · goldAbstract read
In one paragraph

Article in Journal of pain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Drug Safety and Suicidality Risk of Chronic Pain Medications.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

X Michelle Androulakis *Department of Neurology, Columbia VA Healthcare System, Columbia, SC, USA.ORCID 0000-0002-1833-3474
Siyuan Guo *Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-4372-9040
Jiajia ZhangArnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Jason SicoDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Peter WarrenDepartment of Neurology, Columbia VA Healthcare System, Columbia, SC, USA.
Alec GiakasSchool of Medicine, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-0082-1648
Xiaoming LiArnold School of Public Health, University of South Carolina, Columbia, SC, USA.
B Lee PeterlinPennsylvania Headache Center, Camp Hill, PA, USA.
Roy MathewDepartment of Neurology, Columbia VA Healthcare System, Columbia, SC, USA.
Deborah ReyesDepartment of Neurology, Columbia VA Healthcare System, Columbia, SC, USA.
University of South Carolina · USColumbia VA Health Care System · USUnited States Department of Veterans Affairs · USHeadache Care Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectivesA large-scale retrospective analysis of veterans with chronic pain was conducted to examine (1) the annual incidence of suicide attempts (SA) in veterans with chronic headache and other chronic pain conditions, and (2) the risk of SA in men and women with chronic headache and chronic headache concurrent with traumatic brain injury (TBI) as compared to non-headache chronic pain.

methodsThis retrospective study (N=3,247,621) analyzed National Veterans Affair Health Administrative data of patients diagnosed with chronic head, neck, back and other chronic pain from 2000 to 2010. Multivariable Poisson regression was used to explore the relative risks of SA in veterans with chronic headache and chronic headache concurrent with TBI as stratified by sex.

resultsVeterans with chronic headaches had the highest annual incidence of SA (329 to 491 per 100,000) each year among all identified types of chronic pain conditions. Compared to other non-headache chronic pain, chronic headache is associated with increased risk of SA [men RR (1.48), CI (1.37,1.59); women RR (1.64), CI (1.28,2.09)], after adjusting for demographic factors, TBI, and psychiatric comorbidities. The risk increased further when chronic headache is comorbid with TBI [men RR (2.82), CI (2.60, 3.05); women RR (2.16, CI (1.67-2.78)].

conclusionVeterans with chronic headache have a higher risk of SA than those with other chronic pain and women with chronic headache are at a higher risk than men with chronic headache. Chronic headache concurrent with TBI further heightened this risk, especially in men. Our data underscore the importance of identifying specific types of chronic pain in veterans with comorbid TBI and sex disparity associated with SA when targeting suicide prevention measures.

Indexed as

headachemigrainesuicide attemptTBIveteran

Identifiers

PMID34466030
PMCPMC8403028
OpenAlexW3196147220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.