ArticleInternational journal of general medicine2021
Association Between Anion Gap and Mortality in Critically Ill Patients with Cardiogenic Shock.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of anion gap for patients with heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Dynamics of serum anion gaps with in-hospital mortality: Analysis of the multi-open databases.PloS one · 2024Pooled it
- Predictive Value of Anion Gap for Acute Kidney Injury Progression and Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Relationship between time-weighted average anion gap and mortality in septic shock patients: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Association between serum anion gap and all-cause mortality in critically ill patients with Gastrointestinal bleeding: insights from MIMIC-IV database.Scientific reports · 2025Article
- The association between anion gap and prognosis in patients myocardial infarction with congestive heart failure: a retrospective analysis of the MIMIC-IV database.International journal of emergency medicine · 2025Article
- Anion gap predicting 90-Day mortality and guiding furosemide use in ARDS.Scientific reports · 2025Article
- Association of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study.BMC cardiovascular disorders · 2025Article
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- Association between Albumin-Corrected Anion Gap and Mortality in Patients with Cardiogenic Shock.Reviews in cardiovascular medicine · 2024Article
- The correlation between albumin-corrected anion gap and prognosis in patients with acute myocardial infarction.ESC heart failure · 2024Article
- Association between serum anion gap and risk of in-hospital mortality in patients with acute heart failure.Scientific reports · 2024Article
- Association Between Serum Anion Gap and Mortality in Critically Ill Patients with COPD in ICU: Data from the MIMIC IV Database.International journal of chronic obstructive pulmonary disease · 2024Article
- Albumin corrected anion gap for predicting in-hospital death among patients with acute myocardial infarction: A retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2024Article
- The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU.Scientific reports · 2023Article
- Predictive value of the serum anion gap for 28-day in-hospital all-cause mortality in sepsis patients with acute kidney injury: a retrospective analysis of the MIMIC-IV database.Annals of translational medicine · 2022Article
- Relationship of Admission Serum Anion Gap and Prognosis of Critically Ill Patients: A Large Multicenter Cohort Study.Disease markers · 2022Article
- Association of Plasma Anion Gap with 28-Day Inhospital Mortality and 1-Year Mortality of Patients with Alcohol Use Disorder at ICU Admission: A Retrospective Cohort Study.Disease markers · 2022Article
- Machine Learning for Prediction of Outcomes in Cardiogenic Shock.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo epidemiological study has determined the association between the anion gap (AG) and all-cause mortality in critically ill patients with cardiogenic shock (CS). This study was conducted to clarify the relationship between the AG and mortality in CS.
methodsWe extracted clinical data from the public database, MIMIC-III V1.4, by using a generalized additive model to identify the nonlinear relationship between the AG and the 30-day mortality in 1248 intensive care unit patients. Cox proportional hazard models were used to assess the association between the AG and the 30-day, 90-day, and 365-day mortality in CS.
resultsThe AG and 30-day all-cause mortality showed a nonlinear relationship, indicated by a J-shaped curve. In the multivariate analysis, after adjusting for potential confounders, a high AG was associated with an increased risk of 30-day, 90-day, and 365-day all-cause mortality in patients with CS compared with patients who had low AG (hazard ratio [95% confidence interval] 1.62 [1.14-2.30]; 1.35 [1.04-1.84]; and 1.38 [1.03-1.84], respectively). Similar results were shown in Model I (adjusted for age, sex and ethnicity) and in Model II (fully adjusting for age, ethnicity, sex, acute kidney injury stage, CHF, renal disease, stroke, malignancy, respiratory failure, pneumonia, sodium, potassium, chloride, BUN, PT, WBC, pH, creatinine, albumin, glucose, bicarbonate, vasopressor use, diastolic blood pressure, respiration rate, temperature, the Elixhauser Comorbidity Index, SOFA score and SAPSII score).
conclusionThe relationship between the AG and 30-day all-cause mortality followed a J-shaped curve. Higher AG was associated with an increased risk of 30-day, 90-day, and 365-day all-cause mortality in critically ill patients with CS.
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