ArticleNeuropsychiatric disease and treatment2021
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Serum uric acid is associated with shunt dependent hydrocephalus of aneurysmal subarachnoid hemorrhage patients.Neurosurgical review · 2025Article
- A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid.Neuroscience bulletin · 2025Review
- The prognostic significance of uric acid to albumin ratio in patients with aneurysmal subarachnoid hemorrhage following surgical clipping or endovascular interventions: insights from a large cohort study.Frontiers in neurology · 2025Article
- The correlation between the uric acid to high-density lipoprotein cholesterol ratio and stroke.Frontiers in medicine · 2025Article
- More severe initial manifestations and worse short-term functional outcome of intracerebral hemorrhage in the plateau than in the plain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients.Neuropsychiatric disease and treatment · 2024Article
- Fever burden within 24 h after hematoma evacuation predicts early neurological deterioration in patients with intracerebral hemorrhage: a retrospective analysis.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIncreased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH.
methodsThis is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END.
resultsOf the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 µmol/L,
conclusionHigher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering.
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