ArticleClinical interventions in aging2021
Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load.
Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Impact of cardiometabolic factors and AD plasma biomarkers on white matter hyperintensities volume in individuals with cognitive complaints from the global south.Neuroscience · 2026Article
- Racial and ethnic differences in cardiometabolic predictors of white matter hyperintensities burden among males: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2025Article
- Racial ethnic variations in the cardiometabolic determinants and blood pressure of white matter hyperintensities among females-The HABS-HD Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Greater BMI across the lifespan is associated with better midlife cognition: The Bogalusa Heart Study.Scientific reports · 2025Article
- Progress of radiomics research on white matter hyperintensity lesions.Frontiers in neurology · 2025Review
- Identifying obesity and dementia risk: body adiposity and neural connectivity in cognitively normal, mid-life adults.NPJ dementia · 2025Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- White Matter Hyperintensities in Young Patients from a Neurological Outpatient Clinic: Prevalence, Risk Factors, and Correlation with Enlarged Perivascular Spaces.Journal of personalized medicine · 2023Article
- Exploring the combined effects of sleep apnea and APOE-e4 on biomarkers of Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health.Expert review of neurotherapeuticsReview
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7 authors.
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Abstract
objectiveCompared to European Americans, research indicates that African Americans have higher white matter hyperintensity (WMH) load; however, the clinical and biological bases underlying this higher burden are poorly understood. We hypothesize that obesity may explain differences in WMH between African and European Americans.
methodsParticipants enrolled in longitudinal brain aging studies (n=292; 61% Female; 92% European American; mean age=69.6±7.7) completed evaluations including medical exams, neuroimaging, and sociodemographic surveys. Overweight/obese status defined as body mass index ≥30 kg/m
resultsLogistic regression analyses, adjusted for age, sex, hypertension, and smoking history, indicated that age and interaction between race and obesity were significant predictors of WMH, demonstrating that obesity significantly moderated the relationship between race and WMH. Age independently increased the odds of high WMH by 16% (OR=1.16, 95% CI=1.09-1.23, p<0.001). Stratified analysis indicates that older European Americans had increased WMH (OR=1.17, 95% CI=1.09-1.23, p<0.001), while obese African Americans had increased WMH (OR=27.65, 95% CI=1.47-519.13, p<0.05). In a case controlled subgroup matched by age, sex, and education (n=48), African Americans had significantly higher WMH load (27% vs 4%,
conclusionResults denote that age predicted WMH among European Americans, while obesity predicted WMH among African Americans. Matched sample analyses indicate that obesity increases the odds of WMH, though more pronounced in African Americans. These findings suggest that obesity may explain the differential burden of white matter hyperintensity load, signifying public health and clinical importance.
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