ArticleClinical ophthalmology (Auckland, N.Z.)2021
Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis.
Article in Clinical ophthalmology (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Corneal Nerve Fiber Morphology and Biological Age in Healthy Adults.Biomedicines · 2026Article
- Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Corneal Nerve Abnormalities in Chronic Central Serous Chorioretinopathy.Ophthalmology science · 2026Article
- Trigger Factors in Recurrent Corneal Erosion Syndrome.Journal of clinical medicine · 2025Article
- Risk Factors Associated with Corneal Nerve Fiber Length Reduction in Patients with Type 2 Diabetes.Journal of clinical medicine · 2025Article
- Aging and Corneal Nerve Health: Mechanisms of Degeneration and Emerging Therapies for the Cornea.Cells · 2025Review
- CORONIS symposium 2023: Scientific and clinical frontiers in ocular surface innervation.Acta ophthalmologica · 2025Article
- Subclinical corneal inflammation and subbasal nerve alterations in keratoconus detected by in vivo confocal microscopy: a cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Ethnic and sex differences in corneal nerves and corneal epithelial cells in healthy population.Frontiers in medicine · 2025Article
- Harmol used for the treatment of herpes simplex virus induced keratitis.Virology journal · 2024Article
- In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions.Communications biology · 2023Review
- Corneal nerves and their role in dry eye pathophysiology.Experimental eye research · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the normative characteristics of corneal subbasal nerves in different age groups using laser scanning in vivo confocal microscopy (IVCM). PATIENTS AND
methodsThis descriptive observational study recruited healthy subjects (aged 20-60 years) from Siriraj Health-Screening Center. Excluded were individuals who had abnormal ocular symptoms, previous ocular surgery, a history of any diseases related to systemic and/or corneal neuropathy, or abnormal corneal sensitivity. Corneal IVCM (HRT3/Rostock Corneal Module) was performed at the central cornea to analyze the subbasal nerve plexus. The corneal nerve characteristics, comprising the number and density of nerves (main nerve trunks, branches, and total nerves) were analyzed using the NeuronJ program, and the corneal nerve tortuosity was graded. The correlations between the subbasal nerve density, tortuosity and age were then analyzed.
resultsEighty subjects were enrolled, with twenty in each of four age groups (20-30, >30-40, >40-50, and >50-60 years). Overall, the mean number and density of main nerve trunks were 27.93±0.81/mm
conclusionThe corneal subbasal nerve numbers and densities were not significantly different among a healthy population aged 20-60 years. However, there was a trend towards high tortuosity of the corneal nerve in people aged over 40 years.
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