Evidence map›Paper›PMID 34465922›Full record

ArticleNature reviews. Neurology2021

Biomarkers show value of studying dementia in Down syndrome.

Ann-Charlotte Granholm, Aurélie Ledreux

Open access · greenAbstract readComment
In one paragraph

Article in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Down Syndrome Biobank Consortium: A perspective.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ann-Charlotte GranholmKnoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA. Lotta.Granholm-Bentley@du.edu.ORCID http://orcid.org/0000-0002-9685-7599
Aurélie LedreuxKnoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
University of Denver · US

Funding

TAU, AB, SYNUCLEIN AND NITRATIVE/OXIDATIVE DAMAGE IN MCIP01AG014449 · NIA · UNIVERSITY OF PITTSBURGH · PI MUFSON, ELLIOTT JAY · 1997 to 2024
$39.7M
Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Exosome biology in Alzheimer's disease and concussion.R01AG071228 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, LEDREUX, AURELIE · 2021 to 2025
$3.1M
Noradrenergic dysfunction in Down SyndromeRF1AG070153 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI LEDREUX, AURÉLIE · 2020 to 2020
$1.8M
Biological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414k
Resolving Factors in Alzheimers DiseaseR21AG048631 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, SCHULTZBERG, MARIANNE · 2015 to 2016
$357k
NIA NIH HHS P01 AG014449NIA NIH HHS R01 AG071228NIA NIH HHS R21 AG048631NIA NIH HHS R21 AG056974NIA NIH HHS RF1 AG061566NIA NIH HHS RF1 AG070153
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseDown SyndromeAmyloid beta-PeptidesBiomarkersHumansAmyloid beta-PeptidesBiomarkers

Identifiers

PMID34465922
PMCPMC11353155
OpenAlexW3197171310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.