Evidence map›Paper›PMID 34465810›Full record

ArticleScientific reports2021

Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study.

João Fadista, Victor Yakimov, Urmo Võsa, Christine S Hansen, Silva Kasela, Line Skotte, Frank Geller, Julie Courraud, Tõnu Esko, Viktorija Kukuškina and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Polyamine metabolism and anti-tumor immunity.Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 5 countries.

João FadistaDepartment of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark. jpsf@ssi.dk.
Victor YakimovSection of Neonatal Genetics, Danish Centre for Neonatal Screening, Department of Congenital Diseases, Statens Serum Institut, Copenhagen, Denmark.
Urmo VõsaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Christine S HansenSection of Neonatal Genetics, Danish Centre for Neonatal Screening, Department of Congenital Diseases, Statens Serum Institut, Copenhagen, Denmark.
Silva KaselaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Line SkotteDepartment of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark.
Julie CourraudSection of Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Viktorija KukuškinaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Alfonso BuilThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Mads MelbyeDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Thomas M WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
David M HougaardSection of Neonatal Genetics, Danish Centre for Neonatal Screening, Department of Congenital Diseases, Statens Serum Institut, Copenhagen, Denmark.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Jonas Bybjerg-GrauholmSection of Neonatal Genetics, Danish Centre for Neonatal Screening, Department of Congenital Diseases, Statens Serum Institut, Copenhagen, Denmark.
Arieh S CohenSection of Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark. fee@ssi.dk.
Statens Serum Institut · DKUniversity of Tartu · EELundbeck Foundation · DKSankt Hans Hospital · DKBroad Institute · USUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to identify genetic variants associated with regulation of SMOX activity. Replication analysis was performed in two datasets of SMOX gene expression. We then did a Mendelian randomization analysis by testing the association between the SMOX genetic instrument and neuroblastoma, gastric, lung, breast, prostate, and colorectal cancers using GWAS summary statistics. GWAS of spermidine/spermine ratio identified SMOX locus (P = 1.34 × 10

Indexed as

Gene Expression Regulation, EnzymologicGenetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociAdultGene Expression Regulation, NeoplasticHumansInfant, NewbornMendelian Randomization AnalysisNeoplasmsOxidoreductases Acting on CH-NH Group DonorsPhenotypePolyamine OxidaseOxidoreductases Acting on CH-NH Group DonorsPolyamine Oxidase

Identifiers

PMID34465810
PMCPMC8408253
OpenAlexW3198439798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.