ArticleScientific reports2021
Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Functional near-infrared spectroscopy pre-ictal oscillations recorded simultaneously with stereo-EEG.Neuroimage. Reports · 2026Article
- Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data.PloS one · 2026Article
- Gamma amplitude-envelope correlations are strongly elevated within hyperexcitable networks in focal epilepsy.Scientific reports · 2024Article
- Biomimetic Deep Learning Networks With Applications to Epileptic Spasms and Seizure Prediction.IEEE transactions on bio-medical engineering · 2024Article
- A Review of EEG-based Localization of Epileptic Seizure Foci: Common Points with Multimodal Fusion of Brain Data.Journal of medical signals and sensors · 2024Review
- Stability of infraslow correlation structure in time-shifted intracranial EEG signals.Frontiers in network physiology · 2024Article
- The enigma of infra-slow fluctuations in the human EEG.Frontiers in human neuroscience · 2022Article
- Impact of DC-Coupled Electrophysiological Recordings for Translational Neuroscience: Case Study of Tracking Neural Dynamics in Rodent Models of Seizures.Frontiers in computational neuroscience · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.
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