Evidence map›Paper›PMID 34465793›Full record

ArticleNature communications2021

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.

Kerui Wu, Jiamei Feng, Feng Lyu, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Dan Zhao, Abhishek Tyagi, Ravindra Pramod Deshpande and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 141 citations in OpenAlex.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Kerui WuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jiamei FengDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Feng LyuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Fei XingDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-6350-0764
Sambad SharmaDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Yin LiuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Shih-Ying WuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Dan ZhaoDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-5120-6725
Abhishek TyagiDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-0155-2099
Ravindra Pramod DeshpandeDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Xinhong PeiDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Marco Gabril RuizDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Hiroyuki TakahashiDepartment of Pathology, Jikei University School of Medicine, Minato City, Tokyo, Japan.
Shunsuke TsuzukiDepartment of Pathology, Jikei University School of Medicine, Minato City, Tokyo, Japan.
Takahiro KimuraDepartment of Pathology, Jikei University School of Medicine, Minato City, Tokyo, Japan.
Yin-Yuan MoCancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
Yusuke ShiozawaDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-9814-9230
Ravi SinghDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-0750-1804
Kounosuke WatabeDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. kwatabe@wakehealth.edu.ORCID 0000-0001-7441-6322
Wake Forest University · USJikei University School of Medicine · JPFirst Affiliated Hospital of Zhengzhou University · CNHenan Provincial People's Hospital · CNShanghai University of Traditional Chinese Medicine · CNUniversity of Mississippi Medical Center · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Roles of hyaluronic acid in cancer stem cell nicheR01CA173499 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2014 to 2018
$2.3M
Roles of long-non-coding RNA, XIST, in brain metastasis of breast cancerR01CA205067 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2017 to 2021
$2.2M
Role of inflammation and microRNA network in brain metastasis of breast cancerR01CA185650 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2016 to 2020
$1.9M
Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancerR01CA207222 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2017 to 2021
$1.7M
Translational Oncology Training ProgramT32CA247819 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARDEE, TIMOTHY SEBASTIAN, WATABE, KOUNOSUKE · 2020 to 2024
$1.4M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA173499NCI NIH HHS R01 CA185650NCI NIH HHS R01 CA205067NCI NIH HHS R01 CA207222NCI NIH HHS T32 CA247819
6 · The paper itself

Abstract

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence of bone metastasis (>87%) compared to estrogen-negative patients (<56%). To understand the mechanism of this bone-tropism of ER

Indexed as

AnimalsBone NeoplasmsBreast NeoplasmsExosomesFemaleHumansIntegrin-Binding SialoproteinMiceMice, KnockoutMice, NudeMicroRNAsNeoplasm MetastasisOsteoclastsReceptors, EstrogenIntegrin-Binding SialoproteinMicroRNAsMIRN19a microRNA, mouseReceptors, Estrogen

Identifiers

PMID34465793
PMCPMC8408156
OpenAlexW3197685878

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.