Evidence map›Paper›PMID 34465771›Full record

ArticleNature communications2021

Neural signatures of hyperdirect pathway activity in Parkinson's disease.

Ashwini Oswal, Chunyan Cao, Chien-Hung Yeh, Wolf-Julian Neumann, James Gratwicke, Harith Akram, Andreas Horn, Dianyou Li, Shikun Zhan, Chao Zhang and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.

  1. Pooled it
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  7. Natural Frequencies of Levodopa-Induced Dyskinesia in Parkinson's Disease.Annals of clinical and translational neurology · 2026
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Ashwini OswalMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK. ashwini.oswal@ndcn.ox.ac.uk.ORCID 0000-0002-0152-9294
Chunyan CaoDepartment of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Chien-Hung YehMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Wolf-Julian NeumannDepartment of Neurology, Charité University, Berlin, Germany.
James GratwickeDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Harith AkramDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Andreas HornDepartment of Neurology, Charité University, Berlin, Germany.ORCID 0000-0002-0695-6025
Dianyou LiDepartment of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Shikun ZhanDepartment of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Chao ZhangDepartment of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Qiang WangDepartment of Neurology, Charité University, Berlin, Germany.
Ludvic ZrinzoDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0002-6013-4946
Tom FoltynieDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Patricia LimousinDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-5668-5545
Rafal BogaczMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Bomin SunDepartment of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Masud HusainNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-6850-9255
Peter Brown *MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK. peter.brown@ndcn.ox.ac.uk.ORCID 0000-0002-5201-3044
Vladimir Litvak *The Wellcome Centre for Human Neuroimaging, University College London, London, UK. v.litvak@ucl.ac.uk.ORCID 0000-0001-8535-7452
Shanghai Jiao Tong University · CNUniversity College London · GBCharité - Universitätsmedizin Berlin · DEUniversity of Oxford · GBWellcome Centre for Human Neuroimaging · GBBeijing Institute of Technology · CN

Funding

Medical Research Council MC_UU_00003/1Medical Research Council MC_UU_12024/1Medical Research Council MC_UU_12024/5Medical Research Council MK/K005464Wellcome TrustWellcome Trust 203147/Z/16/Z
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across the cortico-basal-ganglia circuit. The relationship between the anatomy of this circuit and oscillatory synchronisation within it remains unclear. We address this by combining recordings from human subthalamic nucleus (STN) and internal globus pallidus (GPi) with magnetoencephalography, tractography and computational modelling. Coherence between supplementary motor area and STN within the high (21-30 Hz) but not low (13-21 Hz) beta frequency range correlated with 'hyperdirect pathway' fibre densities between these structures. Furthermore, supplementary motor area activity drove STN activity selectively at high beta frequencies suggesting that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway. Computational modelling revealed that exaggerated high beta hyperdirect pathway activity can provoke the generation of widespread pathological synchrony at lower beta frequencies. These findings suggest a spectral signature and a pathophysiological role for the hyperdirect pathway in PD.

Indexed as

Neural PathwaysCohort StudiesGlobus PallidusHumansMagnetoencephalographyMotor CortexParkinson DiseaseSubthalamic Nucleus

Identifiers

PMID34465771
PMCPMC8408177
OpenAlexW3197518412

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.