ArticleHorticulture research2021
Metabolite profiling and transcriptome analyses reveal novel regulatory mechanisms of melatonin biosynthesis in hickory.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- A hickory diacylglycerol acyltransferase gene coordinates fatty acid metabolism and aluminum tolerance in plants.The New phytologist · 2026Article
- UHPLC-MS/MS, transcriptomic, and genomic analyses unravel the molecular mechanism on melatonin biosynthesis in Tartary buckwheat sprouts.Food chemistry. Molecular sciences · 2026Article
- Integrated Metabolome-Transcriptome Profiling Identifies JrMYB8 as a Repressor of Polyphenol Biosynthesis in Walnut (Plants (Basel, Switzerland) · 2026Article
- Melatonin: A Dual Protector of Pepper Plants Under Drought Stress via Antioxidant Defence and Glyoxalase-Mediated Cell Detoxification.International journal of molecular sciences · 2025Article
- Integrated Metabolomic and Transcriptomic Analysis Reveals the Roles of Cutin, Suberin, and Flavonoid Metabolism in Apple Peel Deterioration Under Non-Bagging Cultivation.Plants (Basel, Switzerland) · 2025Article
- Exploring the Mechanisms of Amino Acid and Bioactive Constituent Formation During Fruiting Body Development inJournal of fungi (Basel, Switzerland) · 2025Article
- Role of Serotonin in Cadmium Mitigation in Plants.Plants (Basel, Switzerland) · 2025Review
- Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress.Metabolites · 2024Article
- Loss-of-function of LIGULELESS1 activates the jasmonate pathway and promotes maize resistance to corn leaf aphids.Plant biotechnology journal · 2024Article
- Screening of the Candidate Metabolite to Evaluate the Mycelium Physiological Maturation ofJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Integrative analyses of metabolome and transcriptome reveal the dynamic accumulation and regulatory network in rhizomes and fruits of Polygonatum cyrtonema Hua.BMC genomics · 2024Article
- Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oil nanoemulsion against Fusarium oxysporum growth.Scientific reports · 2024Article
- Genome-Wide Identification, Expression Analysis under Abiotic Stress and Co-Expression Analysis ofInternational journal of molecular sciences · 2024Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2024Article
- Combined transcriptome and widely targeted metabolome analysis reveals the potential mechanism of HupA biosynthesis and antioxidant activity inFrontiers in plant science · 2024Article
- An integrated targeted metabolome of phytohormones and transcriptomics analysis provides insight into the new generation of crops:Frontiers in plant science · 2024Article
- Transcriptomic and metabolic analysis unveils the mechanism behind leaf color development inFrontiers in molecular biosciences · 2024Article
- Flavonoid Synthesis-Related Genes Determine the Color of Flower Petals inInternational journal of molecular sciences · 2023Article
- Analysis of Delta(9) fatty acid desaturase gene family and their role in oleic acid accumulation inFrontiers in plant science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have shown that melatonin regulates the expression of various elements in the biosynthesis and catabolism of plant hormones. In contrast, the effects of these different plant hormones on the biosynthesis and metabolism of melatonin and their underlying molecular mechanisms are still unclear. In this study, the melatonin biosynthesis pathway was proposed from constructed metabolomic and transcriptomic libraries from hickory (Carya cathayensis Sarg.) nuts. The candidate pathway genes were further identified by phylogenetic analysis, amino-acid sequence alignment, and subcellular localization. Notably, most of the transcription factor-related genes coexpressed with melatonin pathway genes were hormone-responsive genes. Furthermore, dual-luciferase and yeast one-hybrid assays revealed that CcEIN3 (response to ethylene) and CcAZF2 (response to abscisic acid) could activate melatonin biosynthesis pathway genes, a tryptophan decarboxylase coding gene (CcTDC1) and an N-acetylserotonin methyltransferase coding gene (CcASMT1), by directly binding to their promoters, respectively. Our results provide a molecular basis for the characterization of novel melatonin biosynthesis regulatory mechanisms and demonstrate for the first time that abscisic acid and ethylene can regulate melatonin biosynthesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.