Evidence map›Paper›PMID 34465682›Full record

ArticleJournal of musculoskeletal & neuronal interactions2021

Anticonvulsant use and fracture: a case-control study.

Vinoomika Chandrasekaran, Amanda L Stuart, Julie A Pasco, Sharon L Brennan-Olsen, Michael Berk, Jason M Hodge, Rasika M Samarasinghe, Lana J Williams

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Vinoomika ChandrasekaranDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Amanda L StuartDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Julie A PascoDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Sharon L Brennan-OlsenDepartment of Medicine-Western Health, The University of Melbourne, St Albans, Australia.
Michael BerkDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Jason M HodgeDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Rasika M SamarasingheDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Lana J WilliamsDeakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Deakin University · AUGeelong Hospital · AUOrygen Youth Health · AUUniversity of Melbourne · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women.

methodsData from 1,458 participants (51.8% women) with a radiologically confirmed incident fracture (cases) were compared to 1,796 participants (46.5% women) without fracture (controls). Lifestyle factors, medication use and medical history were self-reported. Associations between anticonvulsant use and fracture were explored using binary logistic regression following adjustment for confounders.

resultsIn men, fracture cases and controls differed in age, smoking history, education, alcohol use, and gonadal hormone supplementation. In women, fracture cases and controls differed by previous fracture history, alcohol use, physical activity levels and use of anti-fracture agents. After adjustment for age, pooled anticonvulsant use was associated with a 3.4-fold higher risk of fracture in men and a 1.8-fold higher risk in women. Following further adjustments for confounders these patterns persisted; a 2.8-fold higher fracture risk in men and a 1.8-fold higher fracture risk in women.

conclusionsAnticonvulsant use was associated with increased fracture risk, independent of demographic, lifestyle, medical and medication related factors. While further studies exploring potential underlying mechanisms are warranted, regular monitoring of bone health in anticonvulsant users with risk factors may be useful.

Indexed as

AnticonvulsantsFractures, BoneBone and BonesBone DensityCase-Control StudiesFemaleHumansMaleRisk FactorsAnticonvulsantsAnticonvulsantCase-Control StudyFractureOsteoporosis

Identifiers

PMID34465682
PMCPMC8426646
OpenAlexW3197248688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.