ArticleJournal of musculoskeletal & neuronal interactions2021
The different correlations between obesity and osteoporosis after adjustment of static mechanical loading from weight and fat free mass.
Article in Journal of musculoskeletal & neuronal interactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- A novel perspective on adolescent bone health: the role of C-reactive protein-triglyceride-glucose index.Pediatric research · 2026Article
- Beyond Weight Loss: Skeletal Considerations in Obesity Treatment.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- The association between body mass index and total lumbar bone mineral density in obese adults: the national health and nutrition examination survey (NHANES) 2011-2020.Hormones (Athens, Greece) · 2025Article
- The mediating role of BMI in the relationship between OSAHS and bone metabolism in male patients with T2DM.Sleep & breathing = Schlaf & Atmung · 2025Article
- Association between life's essential 8 and bone mineral density among adults aged 20-59 years.Scientific reports · 2025Article
- Weight-adjusted waist index associated with bone mineral density in rheumatoid arthritis patients: a cross-sectional study.Clinical rheumatology · 2025Article
- Validation of Three Tools for Estimating the Risk of Primary Osteoporosis in an Elderly Male Population in Beijing.Clinical interventions in aging · 2023Article
- Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2022Article
- Muscle plays a more superior role than fat in bone homeostasis: A cross-sectional study of old Asian people.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore complex correlations between obesity (OB) and osteoporosis (OP) after adjustment of static mechanical loading from weight and fat free mass (FFM).
methodsA total of 3749 Chinese aged ≥65 years were selected from our ongoing cohort study. OB indices and bone mineral density (BMD) were measured for each subject. Linear regression analyses were performed to explore the correlations between OB indices and OP under three adjustment models (unadjusted, adjusted with weight and adjusted with FFM).
resultsUnder no adjustment, three general obesity indices (body mass index: BMI, fat mass: FM, and percentage FM: PFM) were positively associated with BMD at three skeletal sites (P<0.001) in the regression analyses. However, after the adjustment with weight, these associations were mostly significant but reverse i.e., negatively in direction. After adjustment with FFM, the three indices were still positively and significantly (P<0.001) associated with BMD but regression coefficients were smaller compared to the unadjusted associations. Similar associations were observed for central adiposity and lower limb adiposity indices.
conclusionsThe combined relation of OB to OP due to the physiological factors secreted from adipose tissues and the static mechanical loading from FM is positive in direction.
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Identifiers
34465673PMC8426647W3196481005What OpenQuestion holds
Registered trials
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